EFEKTIVITAS FRAKSI AIR DAUN KARAMUNTING (Rhodomyrtus tomentosa (Ait.) Hassk.) TERHADAP EKSPRESI GLUT 2 PADAPANKREAS TIKUS PUTIH (Rattus novergicus) JANTAN GALUR WISTAR MODEL DIABETES MELLITUS

ARINI, MELINDA and Saleh, Muhammad Irsan and Harahap, Debby Handayati (2025) EFEKTIVITAS FRAKSI AIR DAUN KARAMUNTING (Rhodomyrtus tomentosa (Ait.) Hassk.) TERHADAP EKSPRESI GLUT 2 PADAPANKREAS TIKUS PUTIH (Rattus novergicus) JANTAN GALUR WISTAR MODEL DIABETES MELLITUS. Masters thesis, Sriwijaya University.

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Abstract

Background: Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose metabolism due to insulin resistance and decreased pancreatic β-cell function. One of the key factors in glucose regulation is the expression of GLUT 2, a glucose transporter that functions as a glucose sensor. Although drugs such as pioglitazone can improve insulin sensitivity, they may cause long-term side effects. Therefore, plant-based therapeutic alternatives, such as the leaves of Rhodomyrtus tomentosa, are worth exploring. This study aimed to investigate the effect of the aqueous fraction of Rhodomyrtus tomentosa leaves on GLUT 2 expression in the pancreas of male Wistar rats with a diabetes mellitus model. Methods: An experimental study with a post-test only control group design was conducted using male Wistar rats induced with diabetes. The rats were divided into five groups: three treatment groups receiving the aqueous fraction of R. tomentosa leaves at doses of 100, 200, and 400 mg/kgBW, a positive control group (pioglitazone), and a negative control group. GLUT 2 expression was analyzed using immunohistochemistry and assessed by the H-Score method. Results: The aqueous fraction of R. tomentosa leaves increased GLUT 2 expression in a dose-dependent manner. Doses of 200 and 400 mg/kgBW showed significant increases, with the 400 mg/kgBW group approaching the expression levels of the positive control. In contrast, the 100 mg/kgBW dose resulted in lower expression than the negative control, possibly due to subtherapeutic concentrations of active compounds or the use of stored biological materials. Conclusion: The aqueous fraction of R. tomentosa leaves has the potential to enhance GLUT 2 expression in the pancreas of diabetic rat models, particularly at doses of 200 and 400 mg/kgBW. Further studies are required to elucidate the molecular mechanisms and validate its clinical applicability. Keywords: Rhodomyrtus tomentosa, GLUT 2, type 2 diabetes mellitus, aqueous fraction, Wistar rats.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Rhodomyrtus tomentosa, GLUT 2, diabetes melitus tipe 2, fraksi air, tikus Wistar.
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: 04-Faculty of Medicine > 11106-Biomedical Science (S2)
Depositing User: Melinda Arini
Date Deposited: 31 May 2025 04:06
Last Modified: 31 May 2025 04:06
URI: http://repository.unsri.ac.id/id/eprint/174469

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