ANALISIS KESINTASAN IMPROVED GLASGOW PROGNOSTIC SCORE (iGPS) TERHADAP ANGKA MORTALITAS KANKER KOLOREKTAL

ARMANDO, GERRY and Manawan, Efman Efraim Ulrich and Theodorus, Theodorus (2025) ANALISIS KESINTASAN IMPROVED GLASGOW PROGNOSTIC SCORE (iGPS) TERHADAP ANGKA MORTALITAS KANKER KOLOREKTAL. Masters thesis, Sriwijaya University.

Preview	Image RAMA_11707_04012782125006_8846920016_0015096002_cover.jpeg - Cover Image Available under License Creative Commons Public Domain Dedication. Download (94kB) | Preview
	Text RAMA_11707_04012782125006.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11707_04012782125006_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (712kB)
	Text RAMA_11707_04012782125006_8846920016_0015096002_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (719kB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (421kB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (261kB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (245kB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_06.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (222kB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (138kB) | Request a copy
	Text RAMA_11707_04012782125006_8846920016_0015096002_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Background: Colorectal cancer is the third most common malignancy and the second leading cause of cancer-related mortality worldwide, with an incidence rate of 19.5 per 100,000 cases per year and approximately 0.9 million deaths reported in 2020. In Indonesia, colorectal cancer ranks as the third most prevalent cancer with 34,189 cases recorded. Accurate prognostic assessment is essential for determining appropriate therapeutic strategies. One widely used prognostic tool is the Glasgow Prognostic Score (GPS) which is based on serum levels of C-reactive protein (CRP) and albumin. GPS has evolved into the Improved Glasgow Prognostic Score (iGPS), offering greater accuracy in risk stratification and survival prediction, particularly in stage 0–III colorectal cancer. However, the use of iGPS has not been extensively studied in Indonesia. Therefore, this study aims to analyze the association between iGPS and colorectal cancer mortality at Dr. Mohammad Hoesin General Hospital, Palembang, from November 2024 to April 2025. Methods: A total of 33 colorectal cancer patients were analyzed. Each subject’s iGPS was calculated based on CRP and albumin levels, and classified into good, moderate, or poor prognosis groups. The second primary data were collected at the end of study, through a prognostic outcome questionnaire, indicating whether the patient was alive or deceased. The iGPS scores were then analyzed and correlated with the final survival status of the patients. Results: A total of 39.4% of the study subjects were diagnosed with stage 3B colorectal cancer, followed by stage 2A at 36.4%. Analysis revealed a significant association between the Improved Glasgow Prognostic Score (iGPS) and colorectal cancer mortality. Patients with an iGPS of 0 had a 100% survival rate and 0% mortality. In contrast, those with an iGPS of 1 showed a survival rate of 33.3% and a mortality rate of 66.7%, indicating a twofold higher risk of death compared to survival. For patients with an iGPS of 2, the survival rate was 42.1% with a mortality rate of 57%. The Kaplan Meier analysis confirmed a statistically significant association (p < 0.05) between increasing iGPS scores and reduced survival. Conclusion: The Improved Glasgow Prognostic Score (iGPS) is a valid prognostic tool for predicting mortality in patients with colorectal cancer. Higher iGPS scores are significantly correlated with decreased overall survival. Therefore, the iGPS may be integrated into clinical assessment to support risk stratification and survival prediction in colorectal cancer patients. Keywords: Improved Glasgow Prognostic Score (iGPS), Colorectal Cancer, Survival Rate.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > RD Surgery > RD1-811 Surgery
Divisions:	04-Faculty of Medicine > 11707-Surgery (Sp
Depositing User:	Gerry Armando
Date Deposited:	07 Jul 2025 01:45
Last Modified:	07 Jul 2025 01:45
URI:	http://repository.unsri.ac.id/id/eprint/176053

Actions (login required)

View Item