PERBANDINGAN KARAKTERISTIK RETINAL NERVE FIBER LAYER (RNFL) PADA PASIEN GLAUKOMA PRIMER SUDUT TERBUKA DAN PASIEN MIOPIA TINGGI

PUTRI, MUTIA ARNISA and Fidalia, Kamal and Ismail, Ani and Bahar, Erial (2025) PERBANDINGAN KARAKTERISTIK RETINAL NERVE FIBER LAYER (RNFL) PADA PASIEN GLAUKOMA PRIMER SUDUT TERBUKA DAN PASIEN MIOPIA TINGGI. Masters thesis, Sriwijaya University.

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Abstract

Background: Primary Open-Angle Glaucoma (POAG) and high myopia are two ophthalmological conditions that can lead to thinning of the retinal nerve fiber layer (RNFL). POAG is characterized by increased intraocular pressure (IOP), contributing to optic neuropathy and visual field defects. Meanwhile, high myopia is associated with elongation of the eyeball, leading to structural changes in the RNFL. This study aims to compare RNFL characteristics in patients with POAG and high myopia to understand the thinning patterns in each condition. Objective: To determine the characteristics of the retinal nerve fiber layer (RNFL) in patients with primary open-angle glaucoma and high myopia. Methods: This observational study utilized a cross-sectional design conducted at the Glaucoma and Refraction Subdivision of the Ophthalmology Clinic at Dr. Mohammad Hoesin Central General Hospital Palembang and the South Sumatra Provincial Eye Hospital. The study subjects were divided into two groups: POAG patients and high myopia patients, with a total of 50 eyes in each group. RNFL thickness was measured using optical coherence tomography (OCT) and analyzed across four quadrants (superior, inferior, nasal, and temporal). Results: The study results demonstrated a significant difference in RNFL thickness between POAG and high myopia patients (p = 0.01). The average RNFL thickness in POAG patients was lower than in high myopia patients. In POAG, RNFL thinning was more pronounced in the superior and inferior quadrants, consistent with the characteristic pattern of glaucomatous optic neuropathy. Conversely, high myopia patients exhibited more diffuse RNFL thinning, primarily affecting the temporal and nasal quadrants due to mechanical stretching caused by eyeball elongation. Conclusion: RNFL thinning in POAG follows a specific pattern, predominantly affecting the superior and inferior quadrants. In contrast, high myopia presents with more generalized RNFL thinning, with the temporal and nasal quadrants being the most affected areas.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Glaukoma Primer Sudut Terbuka, Miopa Tinggi, Retinal Nerve Fiber Layer, Optical Coherence Tomography
Subjects:	R Medicine > RE Ophthalmology > RE1-994 Ophthalmology R Medicine > RE Ophthalmology > RE91-912 Particular diseases of the eye R Medicine > RE Ophthalmology > RE925-939 Refraction and errors of refraction and accommodation
Divisions:	04-Faculty of Medicine > 11701-Eye Diceases (Sp-1)
Depositing User:	Mutia Arnisa Putri
Date Deposited:	30 Jun 2025 06:11
Last Modified:	30 Jun 2025 06:11
URI:	http://repository.unsri.ac.id/id/eprint/176132

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