OPTIMASI DAN UJI ANTIDIABETES EKSTRAK BIJI DAN KULIT BUAH DUKU (Lansium domesticum Corr.) PADA TIKUS JANTAN DIABETES MELITUS TIPE 2

NINGSIH, TITIS UTAMI WAHYU and Herlina, Herlina and Surya, Nikita (2016) OPTIMASI DAN UJI ANTIDIABETES EKSTRAK BIJI DAN KULIT BUAH DUKU (Lansium domesticum Corr.) PADA TIKUS JANTAN DIABETES MELITUS TIPE 2. Undergraduate thesis, Sriwijaya University.

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Abstract

This study aimed to test the antidiabetic activity of seeds and peels extracts of duku fruits (Lansium domesticum Corr.)potential to decrease blood glucose levels in type 2 diabetes rats by inducing streptozotocin 100 mg/kg BW. The extraction optimation determined using MAE (Microwave-Assisted Extraction) method andpropylene glycol 10-25% solvent. The optimation results with DPPH method showed that 10% propylen glycol has high antioxidant of seeds extract with percentage inhibition value of 67,771% and 25% propylen glycol has high antioxidant of peels extract with percentage inhibition value of 90,227%. The result of AUC0-15 and percentage of decreasing blood glucose levels for positive control group were 456,65 and 65,92%, 3 treatments of seeds extract groups with 50;100;200 mg/kg BW doses, respectively were 785,94 and 73,15%; 684,78 and 72,59%; 557,38 and 60,60%, and 3 treatments of peels extract groups with 50;100;200 mg/kg BW doses, respectively were 544,98 and 61,29%; 556,43 and 66,27%; 799,82 and 72,54%. This result of this study showed that peels and seeds extract duku fruits had an antidiabetic activity and there were no significant differences compared with metformin (p<0,05). ED50 value extrapolating results of seeds extract was 794,33 mg/kg BW and ED50 value extrapolating results of peels extract was12,88 mg/kg BW.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Lansium domesticum Corr., antioxidant, antidiabetic, streptozotocin
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	21 Nov 2019 08:12
Last Modified:	21 Nov 2019 08:12
URI:	http://repository.unsri.ac.id/id/eprint/17651

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