UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoides L.) TERHADAP MENCIT JANTAN (Mus musculus)

AZZAHRA JH, FA'IZA and Lamin, Syafrina and Starlista, Viva (2025) UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoides L.) TERHADAP MENCIT JANTAN (Mus musculus). Undergraduate thesis, Universitas Sriwijaya.

Preview	Image RAMA_48201_08061182126023_Cover.jpg - Cover Image Available under License Creative Commons Public Domain Dedication. Download (320kB) | Preview
	Text RAMA_48201_08061182126023.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061182126023_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_48201_08061182126023_0011116214_0027049502_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (580kB)
	Text RAMA_48201_08061182126023_0011116214_0027049502_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (366kB) | Request a copy
	Text RAMA_48201_08061182126023_0011116214_0027049502_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (320kB) | Request a copy
	Text RAMA_48201_08061182126023_0011116214_0027049502_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (274kB) | Request a copy
	Text RAMA_48201_08061182126023_0011116214_0027049502_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (156kB) | Request a copy
	Text RAMA_48201_08061182126023_0011116214_0027049502_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (208kB) | Request a copy
	Text RAMA_48201_08061182126023_0011116214_0027049502_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (875kB) | Request a copy

Abstract

Bandotan leaves (Ageratum conyzoides L.) contain flavonoid and tannin compounds that act as hemostatic agents. This study aims to determine the most optimal hemostasis effect of varying doses of ethanol extract of bandotan leaves on male mice (Mus musculus). This study used five groups of male mice as samples which were divided into negative control group (NaCMC), positive control (tranexamic acid), and three treatment groups with bandotan leaf ethanol extract doses of 100 mg/kgBB, 150 mg/kgBB, and 250 mg/kgBB given orally for 7 days. Hemostasis parameters were measured using bleeding time with the duke method and clotting time with the slide method observed on day 0 and day 8 of the test. The results showed that ethanol extract of bandotan leaves can accelerate the hemostasis effect significantly (p>0.05) with a dose of 250 mg/kgBB showing effectiveness close to the positive control. The hemostasis mechanism of the extract is related to the flavonoid content that can help the platelet blockage process and has a vasoconstrictive mechanism and tannins have properties as astringents that stop bleeding by precipitating blood proteins. This study shows that ethanol extract of bandotan leaves can be used to accelerate the effect of hemostasis. Keywords: bandotan leaf, bleeding time, blood clotting time, duke method and slide method, hemostasis

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	hemostasis, waktu pembekuan darah, waktu pendarahan
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Fa'iza Azzahra JH
Date Deposited:	07 Jul 2025 06:43
Last Modified:	07 Jul 2025 06:43
URI:	http://repository.unsri.ac.id/id/eprint/177031

Actions (login required)

View Item