PENGARUH PEMBERIAN VITAMIN D TERHADAP PERUBAHAN KADAR PLASMA HOMA-IR, ADIPONEKTIN, HOMOSISTEIN, DAN Hs-CRP SEBAGAI BIOMARKER SINDROM METABOLIK DAN ATEROSKLEROSIS PADA PENDERITA EPILEPSI YANG MENDAPAT OBAT ANTIBANGKITAN ENZIMATIK

HANDAYANI, SRI and Partan, Radiyati Umi and Hafy, Zen and Octaviana, Fitri (2025) PENGARUH PEMBERIAN VITAMIN D TERHADAP PERUBAHAN KADAR PLASMA HOMA-IR, ADIPONEKTIN, HOMOSISTEIN, DAN Hs-CRP SEBAGAI BIOMARKER SINDROM METABOLIK DAN ATEROSKLEROSIS PADA PENDERITA EPILEPSI YANG MENDAPAT OBAT ANTIBANGKITAN ENZIMATIK. Doctoral thesis, Sriwijaya University.

Preview	Image RAMA_11901_04013682025003_Cover.jpg - Cover Image Available under License Creative Commons Public Domain Dedication. Download (526kB) | Preview
	Text RAMA_11006_04013682025003.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11006_04013682025003_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (17MB) | Request a copy
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (607kB)
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (285kB) | Request a copy
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (435kB) | Request a copy
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (81kB) | Request a copy
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (144kB) | Request a copy
	Text RAMA_11006_04013682025003_0017077206_0029127201_0307107501_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (493kB) | Request a copy

Abstract

Introduction: Epilepsy is a manifestation of brain disorders that is associated with high morbidity. Decreased vitamin D levels and incidence of metabolic syndrome in patients receiving antiseizure medications (ASMs) have been reported. This study aimed to analyse the effect of vitamin D administration on changes in plasma levels of HOMA-IR, adiponectin, homocysteine, and hs-CRP as biomarkers of metabolic syndrome and atherosclerosis in epilepsy patients receiving enzymatic AEDs. Methods: This study encompassed a double-blind placebo-controlled randomised controlled trial (RCT) design. The intervention was vitamin D dose of 2,000 IU per day for 12 weeks. Measurements of vitamin D, HOMA-IR, adiponectin, hs-CRP, and homocysteine levels were conducted before and after the intervention and differences in levels were considered significantly different when statistical tests showed p<0.05. Results: 40 patients were enrolled at baseline, of whom 34 completed the study and were allocated in a 1:1 ratio to both groups. Vitamin D, HOMA-IR, adiponectin, homocysteine, and hs-CRP levels before intervention did not differ between the two groups. After the intervention, there was a significant increase in mean 25(OH)D levels in the vitamin D group compared to placebo. There were significant differences in changes in 25(OH)D, adiponectin, and hs-CRP levels (p<0.05), where there was an increase in 25(OH)D and adiponectin levels with a decrease in hs-CRP levels. Conclusion: Vitamin D administration in epilepsy patients receiving enzymatic AEDs has a significant effect on the increase of vitamin D levels as well as changes in adiponectin and hs-CRP biomarker levels as biomarkers of metabolic syndrome and atherosclerosis. Clinical trial registration: This study is registered at ina-crr.id (INA-13022025BB3713B). Keywords: Epilepsy, Antiseizure Medications, Vitamin D, HOMA-IR, adiponectin, homocysteine, hs-CRP

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Epilepsi, Obat Antibangkitan, Vitamin D, HOMA-IR, adiponektin, homosistein, hs-CRP
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM259 Vitamin therapy R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions:	04-Faculty of Medicine > 11106-Biomedical Science (S2)
Depositing User:	Dr. Sri Handayani
Date Deposited:	18 Jul 2025 02:12
Last Modified:	18 Jul 2025 02:12
URI:	http://repository.unsri.ac.id/id/eprint/178917

Actions (login required)

View Item