UJI KESEUAIAN ANTARA PEWARNAAN ZIEHL NEELSEN DAN GENEXPERT MTB/RIF DALAM MENDIAGNOSIS TUBERKULOSIS PARU DEWASA

RAMADHAN, MUHAMMAD SYAHRUL and Rahadiyanto, Kemas Ya’kub and Amalia, Ella (2018) UJI KESEUAIAN ANTARA PEWARNAAN ZIEHL NEELSEN DAN GENEXPERT MTB/RIF DALAM MENDIAGNOSIS TUBERKULOSIS PARU DEWASA. Undergraduate thesis, Sriwijaya University.

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Abstract

Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB). Indonesia’s TB prevalence is ranked second worldwide. The Ziehl Neelsen (ZN) staining is less sensitive than GeneXpert MTB/RIF to diagnose pulmonary TB. The gold standard of TB (culture) takes a longer time, possibly resulting in late diagnosis. The objective of the study was to determine the level of agreement between ZN staining and GeneXpert MTB/RIF in diagnosing adult pulmonary TB in Dr. Mohammad Hoesin General Hospital (RSMH) Palembang. Methods: This study was an agreement test. The samples were patient specimens for the period of January 2016 - March 2017 which were carried out by ZN staining and GeneXpert MTB/RIF to diagnose pulmonary TB in the Clinical Pathology and Microbiology Installation of RSMH Palembang. Data were taken from laboratory results of ZN staining and GeneXpert MTB/RIF. The Cohen’s Kappa statistic was used to measure the level of agreement between the two assays. Results: Of 150 speciments, 69,3% were male patients and 30,7% were females with mean age of 46,71±14,57. Both ZN staining and GeneXpert positivity were 57,3%. As many as 2,67% of specimens were positive for ZN staining and negative for GeneXpert MTB/RIF. Other 2,67% of specimens were ZN negative and GeneXpert MTB/RIF positive. Cohen’s Kappa coefficient was 0,893 which indicated a very good agreement. Conclusion: There is a very good agreement between ZN staining and GeneXpert MTB/RIF in diagnosing adult pulmonary TB in RSMH Palembang.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	MTB, ZN staining, GeneXpert MTB/RIF, pulmonary TB.
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Sri Astuti
Date Deposited:	02 Aug 2019 02:15
Last Modified:	02 Aug 2019 02:15
URI:	http://repository.unsri.ac.id/id/eprint/1814

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