EFEKTIVITAS PENAMBAHAN SUPLEMENTASI VITAMIN C TERHADAP PENURUNAN KONSENTRASI MALONDIALDEHID DAN PERBAIKAN DERAJAT AKTIVITAS PENYAKIT LUPUS ERITEMATOSUS SISTEMIK

HARTANTO, KRISTIAN SUDANA and Kurniati, Nova and Theodorus, Theodorus (2025) EFEKTIVITAS PENAMBAHAN SUPLEMENTASI VITAMIN C TERHADAP PENURUNAN KONSENTRASI MALONDIALDEHID DAN PERBAIKAN DERAJAT AKTIVITAS PENYAKIT LUPUS ERITEMATOSUS SISTEMIK. Other thesis, Sriwijaya University.

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Abstract

Vitamin C is an affordable, over-the-counter antioxidant that acts at multiple cellular levels, from scavenging free radicals to enhancing both endogenous and exogenous antioxidant systems. However, studies on its effects in Systemic Lupus Erythematosus (SLE) remain inconclusive. Some report reductions in disease activity and lipid peroxidation, while others show no significant impact. Data on Vitamin C supplementation in relation to malondialdehyde (MDA) levels and SLE disease activity are limited. This study aimed to evaluated the potential of Vitamin C as an antioxidant adjunct in SLE patients by assessing its effects on serum MDA levels and disease activity using the MEX-SLEDAI score. This study was a pilot, double-blind, randomized controlled trial conducted at RSUP Dr. Mohammad Hoesin Palembang. Participants were patients with mild-to-moderate SLE diagnosed according to the UELAR/ACR 2019 criteria and assessed using the MEX-SLEDAI score. Subjects were randomized to receive either Vitamin C (2X500 mg/day for 2 months) or placebo, in addition to standard SLE therapy. Serum MDA levels and MEX-SLEDAI scores were measured before and after the intervention. Among 34 subjects in the study, the mean malondialdehyde serum concentration was 1,38 ± 0,31 μmol/L. After 2 months of treatment, the vitamin C group demonstrated a signidicant reduction in serum MDA levels (1.38 ± 0.38 vs. 1.09 ± 0.26; p = 0.003) and MEX-SLEDAI scores [median 2 (2–5) vs. 1 (0–2); p = 0.001]. In the placebo group, only the MEX-SLEDAI score showed a significant decrease [3 (2–7) vs. 2 (0–6); p = 0.016], while MDA levels did not change significantly (1.37 ± 0.25 vs. 1.32 ± 0.38; p = 0.518). Between-group comparisons revealed that both the reduction in MDA (p = 0,047) and MEX-SLEDAI (p=0,048) were significantly greater in the vitamin C group compared to placebo. Supplementation with vitamin C 2×500 mg can reduce MEX-SLEDAI scores and decrease serum malondialdehyde levels in patients with mild-to-moderate activity SLE.

Item Type:	Thesis (Other)
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine R Medicine > RC Internal medicine > RC581-607 Immunologic diseases. Allergy
Divisions:	04-Faculty of Medicine > 11802-Internal Medicine (Sp
Depositing User:	Kristian Sudana Hartanto
Date Deposited:	22 Aug 2025 01:51
Last Modified:	22 Aug 2025 01:51
URI:	http://repository.unsri.ac.id/id/eprint/182842

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