KORELASI ANTARA JUMLAH CD4+ CD25+ FOXP3+ SELL TREG DENGAN DERAJAT AKTIFITAS PENYAKIT PADA PASIEN LUPUS ERISTEMATOSUS SISTEMATIK DI RSUP DR. MOHAMMAD HOSEIN PALEMBANG

UMARETA, NURUL RAMADHANI and Yuniza, Yuniza and Legiran, Legiran (2025) KORELASI ANTARA JUMLAH CD4+ CD25+ FOXP3+ SELL TREG DENGAN DERAJAT AKTIFITAS PENYAKIT PADA PASIEN LUPUS ERISTEMATOSUS SISTEMATIK DI RSUP DR. MOHAMMAD HOSEIN PALEMBANG. Other thesis, Sriwijaya University.

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Abstract

Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the presence of autoantibodies against the cell nucleus and involves many organ systems in the body. Treg cells have an important role in maintaining the balance of the immune system and regulating immune tolerance by inhibiting inflammation and dampening the autoimmune response. Dysregulation and disruption of Treg cell activity have been identified in several autoimmune diseases, including SLE. Therefore, Treg cell disorders are considered as an aspect of SLE pathogenesis Methods This correlative analytical observational study conducted 40 samples of Systemic Lupus Erythematosus patients with mild, moderate, and severe degrees of activity older than 18 years who are not in acute and severe infection and do not have other autoimmune diseases in the internal medicine allergy immunology outpatient and inpatient ward of Dr. Mohammad Hoesin general hospital in July-October 2024. The degree of disease activity was assessed using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) score. The number of CD4+ CD25+ FOXP3+ Treg cells was assessed using the flow cytometry method. The correlation between MEX-SLEDAI and Treg cells was evaluated using the Spearman's correlation test. Results 40 subjects (39 women, 1 man) aged ± 37.5 years were recruited in the study. Arthritis and mucocutaneous were the most common manifestations found in all degrees of severity, with results 34 subjects and 38 subjects. Nephritis and hematology were most commonly found in severe degrees of activity. The correlation between CD4+ CD25+ FOXP3+ Treg cells and the degree of disease activity obtained a correlation coefficient (R) of 0.72. A significant correlation between Treg cells and MEX-SLEDAI was observed (p = 0.000) Conclusion There is a significant negative correlation between CD4+ CD25+ FOXP3+ Treg cells and the degree of SLE disease activity. The more severe the degree of SLE activity, the lower the number of Treg cells. Keywords: CD4+ CD25+ FOXP3+ Treg, Systemic lupus erythematosus, MEX-SLEDAI

Item Type:	Thesis (Other)
Uncontrolled Keywords:	CD4+ CD25+ FOXP3+ Treg cells, Regulatory T cells, MEX-SLEDAI, Disease activity, Systemic lupus erythematosus, Autoimmunity
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine R Medicine > RC Internal medicine > RC581-607 Immunologic diseases. Allergy R Medicine > RC Internal medicine > RC581-951 Specialties of internal medicine
Divisions:	04-Faculty of Medicine > 11702-Internal Medicine (Sp
Depositing User:	Nurul Ramadhani Umareta Umareta
Date Deposited:	15 Sep 2025 01:34
Last Modified:	15 Sep 2025 01:34
URI:	http://repository.unsri.ac.id/id/eprint/183829

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