EFEK IMUNOMODULATOR EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina) TERHADAP JUMLAH SEL T CD4 DAN LEUKOSIT PADA TIKUS PUTIH TERINDUKSI Salmonella thypimurium

ARRAHMAN, YOVIA RIZKI and Fitrya, Fitrya and Surya Dharma, Nikita (2016) EFEK IMUNOMODULATOR EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina) TERHADAP JUMLAH SEL T CD4 DAN LEUKOSIT PADA TIKUS PUTIH TERINDUKSI Salmonella thypimurium. Undergraduate thesis, Sriwijaya University.

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Abstract

Vernonia amygdalina Delile (bitter leaf) is one of the Asteraceae. The results of thin layer chromatography test showed positive reaction to phenolic and flavonoid compounds. Phenolics and flavonoids has ability to stimulate specific and nonspecific immune responses. This study aims to determine the immunomodulatory effects ethanol extract of Vernonia leaves against white rats induced Salmonella thypimurium. Immunity parameters measured were the number of CD4 T cells, leukocytes, lymphocytes, monocytes, neutrophils, and macroscopic of spleen. White rats were divided into six treatment groups, namely normal (0,5 mL/kgBB tween 80), negative control (0,5 mL/kgBB tween 80), positive control (Stimuno®), and the extract groups with a therapeutic dose 200 mg/kgBW, 400 mg/kgBW, and 800 mg/kgBW. Salmonella thypimurium was injected in all treatment groups except the normal. It was injected intraperitoneally on day 8 with a dose 0.5 mL x 105 CFU/mL. Total phenolics and flavonoids contained in the ethanol extract of Vernonia leaves are 184.23 ± 2.794 mgGAE/g extract and 131.48 ± 3.207 mg/g extract. Tested groups showed an increase the number of CD4 T cells, leukocytes, lymphocytes, monocytes, and neutrophils were significantly (p<0.05). It is summarized that the higher value ethanol extract of african leaves dose would cause higher value of CD4 T cell, leukocytes, limphocytes, monocytes, and neutrophils. Ethanol extract of leaves Africa at a dose of 800 mg/kgBW can cause hyperplasia or hypertrophy of the spleen.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Vernonia amygdalina Del, Salmonella thypimurium, CD4 T Cell, Leukocyte, Monocyte, Lymphocyte, Neutrophil
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 26 Nov 2019 08:50
Last Modified: 26 Nov 2019 08:50
URI: http://repository.unsri.ac.id/id/eprint/18615

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