UJI ANTIDIABETES EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon.L) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI ALOKSAN DAN HISTOPATOLOGI PANKREAS

NOVIARNY, HERIN and Herlina, Herlina and Amriani, Annisa (2019) UJI ANTIDIABETES EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon.L) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI ALOKSAN DAN HISTOPATOLOGI PANKREAS. Undergraduate thesis, Sriwijaya University.

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Abstract

In the research of testing antidiabetic test of ethanol extract of melinjo leaf (Gnetum gnemon L.) to male rats induced by alloxan and pancreatic histophatology observation in these rats. Melinjo leaf contains secondary metabolites such as flavonoids, tannins, saponins and phenolics that have antidiabetic activity. The aim of the research ar to find out the effect of ethanol extract of the decrease in blood glucose levels and pancreatic histopathological observation and see ED50 of the ethanol extract of leaves melinjo. Melinjo leaf ethanol extract dose variation is made with 125, 250, and 500 mg/kg. As a positive control comparator used insulin dose 1 IU/kg, negative control used suspension CMC Na 0,5% and dick normal without treatment. Testing was done by measuring fasting blood glucose levels of the mice with the GOD-PAP enzymatic method using a photometer DTN-410-K on days 0, 10, 15, and 20. The histopathology preparations made according to standard procedures with hematoxylin-eosin staining. The average yield% PKGD for positive control of 40,68%, and 3 treatment groups melinjo leaf ethanol extract doses of 125, 250, and 500 mg/kg respectively 31.48, 34.39, and 42.90%. ED50 value of the ethanol extract of the leaves melinjo ie 720,86 mg/kg. Histopathologic features showed necrosis of the endocrine cells in the islets of Langerhans negative group and an improvement in the positive control group and three treatment groups. Repair is best seen in the group of 500 mg/kg.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun melinjo, antidiabetes, aloksan, kadar glukosa darah, histopatologi pankreas
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 3465 not found.
Date Deposited:	03 Dec 2019 08:03
Last Modified:	05 Dec 2019 04:57
URI:	http://repository.unsri.ac.id/id/eprint/19492

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