KARAKTERISASI DAN UJI PENETRASI SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) PEMBAWA ERGOCALCIFEROL DENGAN PENGARUH STABILIZER POLY(VINYL ALCOHOL)

FITHRI, MUHAMMAD and Mardiyanto, Mardiyanto and Herlina, Herlina (2017) KARAKTERISASI DAN UJI PENETRASI SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) PEMBAWA ERGOCALCIFEROL DENGAN PENGARUH STABILIZER POLY(VINYL ALCOHOL). Undergraduate thesis, Sriwijaya University.

[img] Text
RAMA_48201_08121006072.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (4MB) | Request a copy
[img]
Preview
Text
RAMA_48201_08121006072_0010037102_0003077102_01_front_ref.pdf - Accepted Version
Available under License Creative Commons Public Domain Dedication.

Download (1MB) | Preview
[img] Text
RAMA_48201_08121006072_0010037102_0003077102_02.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (547kB) | Request a copy
[img] Text
RAMA_48201_08121006072_0010037102_0003077102_03.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (234kB) | Request a copy
[img] Text
RAMA_48201_08121006072_0010037102_0003077102_04.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (472kB) | Request a copy
[img] Text
RAMA_48201_08121006072_0010037102_0003077102_05.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (97kB) | Request a copy
[img] Text
RAMA_48201_08121006072_0010037102_0003077102_06_ref.pdf - Bibliography
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (465kB) | Request a copy
[img] Text
RAMA_48201_08121006072_0010037102_0003077102_07_lamp.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (3MB) | Request a copy

Abstract

Ergocalciferol is used as a medicine to treat rachitis that classified in the Biopharmaceutics Classification System (BCS) class IV. Low solubility and permeability of ergocalciferol will reduce drug bioavailability and affect the absorption. This research aims to increase solubility and permeability of ergocalciferol, so the drug can be applied topically. Ergocalciferol was formulated by single emulsion solvent evaporation method into 3 formulas (1.6; 2.0; and 2.4%) using Poly(Lactic-co-Glycolic Acid) (PLGA) as polymer and Poly(Vinyl Alcohol) (PVA) as stabilizer. Determination of entrapment efficiency percentage (%EE) for formula 1 was 75.92 ± 0.735%, formula 2 was 67.96 ± 0.790 and formula 3 was 53.8 ± 2.097%. Based on result of percent EE, the optimum formula of submicron particle PLGA-ergocalciferol is formula 1 that contain 40 mg PVA. The result of submicro particles characterization such as diameter and particles distribution (Poly Dispersity Index/PDI) and potential zeta using Particle Size Analyzer (PSA) were 270.7 nm; 0.208; and -0.2 mV. Morphology particle of optimum formula was observed using Transmission Electron Microscope (TEM) showed spheric particles which were homogen with a PDI of 0.15. There was a difference in the in-vitro diffusion test results by using Franz diffusion cell, PLGA-ergocalciferol submicro particles was 23.305 ± 0.118%, compared with pure ergocalciferol solution with diffusiom percentage was of 9.381 ± 0.008%.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Ergocalciferol, PLGA, PVA, Submicron Particle, Permeability
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS125-131.9 Formularies. Collected prescriptions
R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 03 Dec 2019 05:34
Last Modified: 03 Dec 2019 05:34
URI: http://repository.unsri.ac.id/id/eprint/19726

Actions (login required)

View Item View Item