OPTIMASI DAN KARAKTERISASI FORMULA SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) PEMBAWA BETAMETASON VALERAT DENGAN VARIASI KONSENTRASI POLY(VINYL ALCOHOL) DAN WAKTU SONIKASI

REFTI, WINESFIN and Mardiyanto, Mardiyanto and Fithri, Najma Annuria (2017) OPTIMASI DAN KARAKTERISASI FORMULA SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) PEMBAWA BETAMETASON VALERAT DENGAN VARIASI KONSENTRASI POLY(VINYL ALCOHOL) DAN WAKTU SONIKASI. Undergraduate thesis, Sriwijaya University.

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Abstract

Preparation of betamethasone valerate (BMV) into submicro particle scale aims to resolve the solubility problem (biopharmaceutics classification system II) and to increase penetration through the skin. The method of emulsion solvent evaporation is used in preparing BMV encapsulated by PLGA (poly (lactic-co-glycolic Acid) as polymer and PVA poly(vinyl alcohol) as stabilizer. The optimization of BMV submicro particle formula with factorial design 22 in Design Expert® 10 program is useful to determine the effect of PVA concentration and sonication time factors on %EE (percent efficiency encapsulation), pH, and concentration after stability testing with heating cooling cycle method as responses. The proportion of optimum formula components obtained were 50 mg PVA concentration and 10 minutes sonication time with the response values which resulted %EE of 73.000%, pH of 4.800, and percent concentration of 62.057%. The optimum of PVA concentration and sonication time were known to stabilize PLGA-BMV submicro particles and to make particle in submicro scale that tend to be homogeneously distributed. The resulting diameter, PDI (poly dispersity index), and zeta potential analysis of the optimum formula were 342.700 nm, 0.104, and -12.200 mV. Respectively of particle morphology using transmission electron microscopy showed spheric shape particle (round). Particle penetration testing has been done through in vitro diffusion test, using the Franz Diffusion Cell. The diffusion test showed the highest diffusion percent value on submicro particles of PLGA-BMV (23.067% ± 0.055) compared with pure BMV (18.007% ± 0.002), and comercial BMV dosage form (19.506% ± 0.071). The compartement analysis using WinSAAM® program showed that optimum formula followed 3 compartment model (lag time). Analysis of the dissolution rate with the high DE value parameter showed that submicro particles of PLGA-BMV (84.211% ± 1.943) increased the drug released process compared to pure BMV (10.912% ± 0.246). The release rate and mechanism of PLGA-BMV followed zero order and Korsmeyer-Peppas with super case II transport model. Stability of dosage form was tested through heating cooling cycle method showed a decrease of insignificant level in each cycle.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Betamethasone Valerate, Submicro Particles, PLGA, PVA, Sonication Time
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 03 Dec 2019 08:53
Last Modified: 03 Dec 2019 08:53
URI: http://repository.unsri.ac.id/id/eprint/19832

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