UJI AKTIVITAS ANTIHIPERLIPIDEMIA EKSTRAK ETANOL BIJI PETAI (Parkia speciosa Hassk.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI PROPILTIOURASIL

HAPSARI, NICKY WAHYUNI and Fitrya, Fitrya and Amriani, Annisa (2019) UJI AKTIVITAS ANTIHIPERLIPIDEMIA EKSTRAK ETANOL BIJI PETAI (Parkia speciosa Hassk.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI PROPILTIOURASIL. Undergraduate thesis, Sriwijaya University.

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Abstract

Petai’s Seeds (Parkia speciosa Hassk.) contain flavonoid, alkaloid, tannin, saponin, steroid, and phenolic so it could act as antihyperlipidemia. This study purposed to know antihyperlipidemia effect of ethanol extract petai’s seeds towards total cholesterol level and LDL (Low Density Lipoprotein) level reduction. Male wistar albino rats were divided into 5 groups, negative control group (Na CMC 0.5%), positive control group (simvastatin 0,193 mg/200 gBB), and three treatment groups of ethanol extract petai’s seeds with dosage 99,5 mg/200 gBB, 199 mg/200 gBB, and 398 mg/200 gBB. The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract given for the next 15 days. Rats total cholesterol level after induced can be stated as hyperlipidemia if >54 mg/dL and LDL level >27 mg/dL. The result showed ethanol extract petai’s seeds dosage 398 mg/200 gBB could reduce total cholesterol level and LDL level significantly of 30,52±3,2581 mg/dL and 16,46±2,3044 mg/dL. This point indicated that the ethanol extract petai’s seeds has an antihyperlipidemia activity and there is significant difference compared with negative control group (p<0.05). According to the relation between percentage reduction level of total cholesterol with dose, value of ED50 of ethanol extract petai’s seeds is 582,11 mg/200 gBB and for LDL reduction level is 356,06 mg/200 gBB. Keyword: Parkia speciosa Hassk., antihyperlipidemia, total cholesterol, and LDL.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Parkia speciosa Hassk., antihiperlipidemia, kolesterol total, dan LDL
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Nicky Wahyuni Hapsari
Date Deposited: 06 Dec 2019 04:00
Last Modified: 06 Dec 2019 04:00
URI: http://repository.unsri.ac.id/id/eprint/20173

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