OPTIMASI FORMULA SEDIAAN INTRANASAL NANOPARTIKEL EKSTRAK AIR DAUN GAMBIR (Uncaria gambir Roxb.) DENGAN VARIASI JENIS ALAT DAN LAMA WAKTU PENGECILAN UKURAN

CONTESA, EMILIA and Fitrya, Fitrya and Permata Wijaya, Dina (2019) OPTIMASI FORMULA SEDIAAN INTRANASAL NANOPARTIKEL EKSTRAK AIR DAUN GAMBIR (Uncaria gambir Roxb.) DENGAN VARIASI JENIS ALAT DAN LAMA WAKTU PENGECILAN UKURAN. Undergraduate thesis, Sriwijaya University.

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Abstract

Gambir is a plant that has a high antioxidant activity. Antioxidant contained in the gambir is used in the treatment of Alzheimer’s disease treatment in dosage forms nanoparticles can conduct a gambir extracts are targeted. Preparations nanoparticles peel extract prepared by ionic gelation method with a matrix of chitosan, sodium tripoliposfat. Formulation of nanoparticles using Expert® Design application version 10 factorial design. Factors analyzed to obtain the optimum formula of the preparation of nanoparticles is the kind of tool size reduction and downsizing long time. Optimum formula obtained by performing optimization on every formula with desirability value 0,754 in formula 1 are the type of ultra turrax apparatus for 5 minutes. Data optimum formula to the organoleptic response that precipitates yet easily dispersed, pH 4,652, percent of EE 97,458%, percent decreased levels of stability 0,159%, viscosity 1,200 cPs, sedimentation time 660 seconds, redispersion 3,365 and 11,842 ml of sedimentation volume. Characterization of nanoparticles in the optimum formula obtained particle size of 1019,9 nm with 0,393 PDI and zeta potential of +7 mV. Diffused percent nanoparticle preparation that is 67,1238% and 48,5478% extract.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: gambir water extract, intranasal, chitosan, nanoparticles, Alzheimer
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Emilia Contesa
Date Deposited: 09 Dec 2019 02:34
Last Modified: 09 Dec 2019 02:34
URI: http://repository.unsri.ac.id/id/eprint/20174

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