PENGARUH VARIASI KONSENTRASI KOLESTEROL TERHADAP KARAKTERISTIK SEDIAAN INTRANASAL LIPOSOM OKSKARBAZEPIN

RAHAYU, PUTRI SITI and Untari, Budi and Wijaya, Dina (2019) PENGARUH VARIASI KONSENTRASI KOLESTEROL TERHADAP KARAKTERISTIK SEDIAAN INTRANASAL LIPOSOM OKSKARBAZEPIN. Undergraduate thesis, Sriwijaya University.

	Text RAMA_4820_08061381520048.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061381520048_00102658002_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (956kB)
	Text RAMA_48201_08061381520048_00102658002_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (531kB) | Request a copy
	Text RAMA_48201_08061381520048_00102658002_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (441kB) | Request a copy
	Text RAMA_48201_08061381520048_00102658002_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (432kB) | Request a copy
	Text RAMA_48201_08061381520048_00102658002_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (86kB) | Request a copy
	Text RAMA_48201_08061381520048_00102658002_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (235kB) | Request a copy
	Text RAMA_48201_08061381520048_00102658002_07_Lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (908kB) | Request a copy
	Text RAMA_48201_08061381520048_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (10MB) | Request a copy

Abstract

Oxcarbazepine is used as monotherapy or additional therapy for partial attacks (simple, complex, secondary general). This study aims to formulate oxcarbazepine liposomes which have the ability to deliver preparations to penetrate the nasal mucosa with the components of Soya lecithin and cholesterol using thin film hydration method. The effect of cholesterol concentration was observed on organoleptic responses, percent EE, pH, viscosity and stability decreased. The optimum formula response was organoleptis white liquid and soybean odor, percent EE 92.6327%, pH 8,47, viscosity 1,090847 cP, stability decreased 0,3447%. The optimum formula produces a particle size of 579 nm with a PDI value of 0.347 and a potential zeta - 99.38 mV. The percent diffusion of oxcarbazepine liposomes was 62.2635% larger than usual pure oxcarbazepine 41.9705%. The compartemental analysis of the optimum formula showed that oxcarbazepine liposomes followed the lag time compartment model. All the results (except pH) of this analysis indicate that oxcarbazepine liposomes can be used in intranasal drug delivery. Keywords: intranasal, liposomes, oxcarbazepine, cholesterol, thin film hydration

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	intranasal, liposomes, oxcarbazepine, cholesterol, thin film hydration
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 584 not found.
Date Deposited:	06 Aug 2019 03:05
Last Modified:	19 Aug 2019 04:21
URI:	http://repository.unsri.ac.id/id/eprint/2130

Actions (login required)

View Item