FORMULASI DAN KARAKTERISASI SEDIAAN INTRANASAL LIPOSOM FENITOIN MENGGUNAKAN METODE HIDRASI LAPIS TIPIS DENGAN PENGARUH VARIASI KONSENTRASI KOLESTEROL

ADIYATAMA, DIAN and Untari, Budi (2019) FORMULASI DAN KARAKTERISASI SEDIAAN INTRANASAL LIPOSOM FENITOIN MENGGUNAKAN METODE HIDRASI LAPIS TIPIS DENGAN PENGARUH VARIASI KONSENTRASI KOLESTEROL. Undergraduate thesis, Sriwijaya University.

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Abstract

Sodium phenytoin, a form of salt from phenytoin, is one of the first-line antiepileptic drug that is widely used through activation of Sodium-Potassium ATP-ase, resulting in inactivation of the Na channel and inhibited depolarization. Intranasal preparations of phenytoin are formulated to increase the effectiveness of epilepsy treatment with brain targets made in the form of liposome with soya lesitin, cholesterol and chloroform observed for organoleptic response, percent EE, pH, stability level and viscosity. The response of the optimum formula was EE percent 95,65833%, pH 7,556667, stability levels 95,60833% and viscosity 1,13809. The optimum formula produces particle size of 522,4 nm with PDI values of 0.368 and potential zeta of -58 mV. Percent diffused by phenytoin nanoparticles was 54,85694% compared to pure phenytoin by 25,13806%. Evaluation results indicate that phenytoin have good characteristics as intranasal preparations. Keyword(s): Sodium phenytoin, intranasal, liposome, cholesterol, thin layer hydration, epilepsy

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Sodium phenytoin, intranasal, liposome, cholesterol, thin layer hydration, epilepsy
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 583 not found.
Date Deposited:	06 Aug 2019 08:12
Last Modified:	06 Aug 2019 08:12
URI:	http://repository.unsri.ac.id/id/eprint/2131

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