HUBUNGAN ANTARA KADAR CD4 DAN INFEKSI OPORTUNISTIK PADA PASIEN INFEKSI HIV USIA DEWASA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG PERIODE 1 JUNI 2018 - 30 JULI 2019

LETISSIA, ADELA NADYA and Adnindya, Msy.Rulan (2019) HUBUNGAN ANTARA KADAR CD4 DAN INFEKSI OPORTUNISTIK PADA PASIEN INFEKSI HIV USIA DEWASA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG PERIODE 1 JUNI 2018 - 30 JULI 2019. Undergraduate thesis, Sriwijaya University.

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Abstract

Introduction. A person who infected with HIV can have various opportunistic infection from all the pathogens, such as viruses, bacteria, fungi, and parasites. Opportunistic infections are closely related to the disease progression which weakens the patient's immune system that characterized by decreased CD4 counts in the body. This study aims to discuss the relationship between CD4 cell count decline and the type of infection that occurred in patients with HIV infection. Methods. This study is an analytic study with a cross-sectional design. The subject of this study is the medical record data of HIV infected patients in RSUP dr. Mohammad Hoesin Palembang for the period of 1 July 2018 - 30 June 2019 who met the inclusion criteria. Data were taken by consecutive sampling technique then analyzed using the chi-square test. Results. From 51 sample data that was collected, CD4 count in HIV patients’ varies between 1-300 cell/µL with average CD4 count was 39.422 cell/µL. All HIV infection patients had opportunistic infections and 35 of them had ≥ 2 infections, bringing the total number of opportunistic infections to 84. Oral candidiasis (34.5%) and pulmonary tuberculosis (23.8%) were the most opportunistic infections found in patients' HIV infection. The causes of opportunistic infections include bacteria (40.5%), fungi (39.3%), parasites (13.1%), and viruses (7.1%). The bivariate test showed a significant relationship between CD4 cell counts and the number of opportunistic infections (p = 0.005) with CD4 levels <39,422 with a risk of 6.356 times higher to experience more than one opportunistic infection (95% CI = 1.731 - 23.333). Analysis between CD4 levels and pathogenic causes of infection found that the relationship to viral infection was not significant (p = 1,000), the relationship was not significant to bacterial infections (p = 0.576) and fungi (p = 0.915), and there was a significant relationship to parasites ( p = 0.009). Conclusion. Decreased CD4 levels increase the occurrence of opportunistic infections in patients with HIV infection and have a significant difference to opportunistic infections caused by parasites.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Infeksi HIV, Kadar CD4, Infeksi Oportunistik
Subjects: R Medicine > RC Internal medicine > RC109-216 Infectious and parasitic diseases
R Medicine > RC Internal medicine > RC955-962 Arctic medicine. Tropical medicine
Divisions: 04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User: Users 4039 not found.
Date Deposited: 09 Jan 2020 06:13
Last Modified: 09 Jan 2020 06:13
URI: http://repository.unsri.ac.id/id/eprint/23608

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