UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE FIXED DOSE PROCEDURE

LESTARI, AYU ADELIA and Herlina, Herlina and Amriani, Annisa (2020) UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE FIXED DOSE PROCEDURE. Undergraduate thesis, Sriwijaya University.

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Abstract

Melinjo leaves has several benefits as antidiabetic, antihyperglycemia, antioxidant and diuretic. The result of the screening of the pythochemical showed that leaves of beluntas contained alcaloid, flavonoid, saponin, fenolic and tanin. In this experiment the acute toxicity test of ethanol extract of melinjo (Gnetum gnemon L.) leaves on male white rats of wistar strain with fixed dose procedure method. Ethanol extract of melinjo leaves was obtained by maceration using ethanol 70%. From the observational study, the dose 2000 mg/kgBW was chosen as starting dose for the main study. Experimental animal subject used in the main study were 10 male white rats of wistar which were divided into 2 group, normal group and treatment group with a dose of 2000 mg/kgBW. The result showed that there were no death or toxicity sign in all experimental animals. During the 14 days observation period, there were no significant changes in body weight of rats either in normal control group and treatmen group with a dose of 2000 mg/kgBW (p>0,05). Melinjo leaves had no effect on the macroscopic organs of liver, kidneys and heart of the test animals (p>0,05). The average level of biochemical parameters in the normal group is SGOT 54,13±11,428 U/L, SGPT 47,476±21,655 U/L, creatinine 0,632±0,199 mg/dL, and urea 14,46±2,267 mg/dL, while the 2000 mg/kgBW dose group is SGOT 60,192±14,198 U/L, SGPT 55,968±22,998 U/L, creatinine 0,756±0,204 mg/dL, dan urea 16±2,561 mg/dL. It showed that the ethanol extract of melinjo leaves with a dose of 2000 mg/kgBW are the category of practically non-toxic.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun Melinjo, Gnetum gnemon L., toksisitas akut, fixed dose procedure
Subjects:	R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 5845 not found.
Date Deposited:	03 Jun 2020 14:26
Last Modified:	03 Jun 2020 14:26
URI:	http://repository.unsri.ac.id/id/eprint/29607

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