STANDARDISASI DAN UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus champeden) DENGAN METODE ACUTE TOXIC CLASS

AMELIA, MUFLIHAH and Fitrya, Fitrya and Annisa S, Amriani (2020) STANDARDISASI DAN UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus champeden) DENGAN METODE ACUTE TOXIC CLASS. Undergraduate thesis, Sriwijaya University.

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Abstract

Cempedak (Artocarpus champeden) leaves has antioxidant and antibacterial activity. The results of phytochemical screening show that cempedak’s leaves contained secondary metabolites such as flavonoids, saponins, steroids, and tannins. Cempedak’s leaves as ingredients of medicine must be done by toxicity test to know its safety. Acute toxicity test of cempedak’s leaves extract on female rats of wistar strain with Acute Toxic Class method. Cempedak’s leaves was done by maceration using ethanol 96%. The initial dose for the main test was determined by preliminary test is 2000 mg/kgBW. There are 2 groups, each groups with 3 rats, normal group and 2000 mg/kgBW dose group. This study showed that 2000 mg/kgBW dose group were not symptoms of toxic and deaths on rats. The weight’s changes during 14 days of observation on normal group and 2000 mg/kgBW dose group were not significant different (p>0,05). The macroscopic organs of liver, kidney, and heart on normal group and 2000 mg/kgBW dose group were not significant different (p>0,05). The normal group’s the averages of biochemical parameters were SGOT 186,33 ± 10,16 U/L, SGPT 64 ± 3 U/L, creatinine 0,64 ± 0,09 mg/dL, and ureum 35,57 ± 1,91 mg/dL. The 2000 mg/kgBW dose groups’s averages of biochemical parameters were SGOT 280,33 ± 65,91 U/L, SGPT 90 ± 27,06 U/L, creatinine 0,59 ± 0,39 mg/dL, and ureum 47,52 ± 6,09 mg/dL. This study shows that dose range of cempedak’s leaves ethanol extract acute toxicity is more than 2000 mg/kgBW.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun cempedak, Artocarpus champeden, toksisitas akut, acute toxic class
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 7136 not found.
Date Deposited:	13 Aug 2020 08:03
Last Modified:	13 Aug 2020 08:03
URI:	http://repository.unsri.ac.id/id/eprint/32716

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