UJI HEPATOPROTEKTOR EKSTRAK ETANOL DAUN KIRINYUH (Chromolaena odorata L.) DAN HISTOPATOLOGI HEPAR PADA TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI PARACETAMOL

NGULWIYAH, CAHYANI PUTRI and Herlina, Herlina and Solihah, Indah (2019) UJI HEPATOPROTEKTOR EKSTRAK ETANOL DAUN KIRINYUH (Chromolaena odorata L.) DAN HISTOPATOLOGI HEPAR PADA TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI PARACETAMOL. Undergraduate thesis, Sriwijaya University.

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Abstract

Kirinyuh leaves (Chromolaena odorata L.) contain flavonoids which have the potential hepatoprotector activity and need to be proven. This study of the hepatoprotector activity of the kirinyuh leaf ethanol extract was carried out based on the parameters of the SGPT and SGOT enzymes and the histopathological description of the rats induced by paracetamol. The test carried out for 8 days with 30 rats in which group 1 was the normal control group were only given 1% sodium CMC, rats in group II as negative control were given paracetamol 2 g/kgBW, rats in group III as positive control were given N-acetylcysteine, and rats in groups IV, V, and VI as test group was given extract of 200, 400, 800 mg/kgBW doses. The average of SGPT on normal, negative, positive, and test group of 200, 400, and 800 mg/kgBW doses were 90,59 ± 16,43; 361,09 ± 10,35; 90,86 ± 9,926; 172,95 ± 23,01; 125,23 ± 20,57; 97,64 ± 19,41 U/L. While the average of SGOT on normal, negative, positive, test group of 200, 400, dan 800 mg/kgBB doses were 174,48 ± 32,23; 460,56 ± 42,88; 194,11 ± 20,94; 349,28 ± 17,31; 277,53 ± 36,95; 236,71 ± 17,62 U/L. Respectively the result indicated that kirinyuh’s leaf ethanolic extract significantly (p<0.05) lowered SGPT and SGOT levels compared to control negative group and influenced the histopathology pictures of paracetamol-induced rats’ liver. The results of this study prove that the ethanol extract of kirinyuh leaf was treated III with a dose of 800 mg/kgBW has the highest hepatoprotector activity compared to treatment of I dose 200 mg/kgBW and treatment of II dose 400 mg/kgBW, marked by the value of SGPT and SGOT approaching normal conditions, and also normal hepatic histopathology without degeneration of hepatocyte, bleeding of liver tissue or necrosis cell although toxic dose of paracetamol has been given. Keyword(s): Chromolaena odorata L., hepatoprotector, SGPT, SGOT, histopathology

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: SGOT, SGPT, HISTOPATOLOGI, HEPATOPROTEKTOR
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Cahyani Putri Ngulwiyah
Date Deposited: 09 Aug 2019 06:23
Last Modified: 09 Aug 2019 06:23
URI: http://repository.unsri.ac.id/id/eprint/3325

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