PREPARASI DAN KARAKTERISASI MIKROPARTIKEL NATRIUM ALGINAT YANG DILAPISI KITOSAN PENGENKAPSULASI EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP PERTUMBUHAN Escherichia coli DAN Staphylococcus aureus

OKTALITA, YOLA and Mardiyanto, Mardiyanto and Untari, Budi (2018) PREPARASI DAN KARAKTERISASI MIKROPARTIKEL NATRIUM ALGINAT YANG DILAPISI KITOSAN PENGENKAPSULASI EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP PERTUMBUHAN Escherichia coli DAN Staphylococcus aureus. Undergraduate thesis, Sriwijaya University.

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Abstract

Papaya (Carica papaya L) is an evergreen plant that almost all parts of the plants can be utilized in the traditional medicine. Leaf of papaya is the part which often used as traditional medicine. Papaya leaves are containing many active substances which has antimicrobial activity of proteolytic and as such the content of enzymes papain, alkaloids, tocophenol, and carpain flavonoids. This research aims to know the antibacterial activity, characteristics of micro particles of papaya leaf, to know the percent usage of the polymer Chitosan encapsulation efficiency with a alginat sodium and ethanol extracts of leaves of the papaya. The making of micro particles of extract of papaya leaves etanol by using metodegelasi ionic and antibacterial activity method using paper discs. The test results generated value% EE of formula 1, 2, and 3 in a row of 99.71, 99.86, and 99.92. Formula three showed the value of the largest% EE so that is able to extract encapsulation getting bigger and have the best pharmacological activity then selected as optimum formula. Test results showed antibacterial activity against Staphylococcus drag zone of aureus 2,076 ± 0.083 mm (weak inhibitory zone) and Escherichia coli sebesar3, 11 ± 0.107 mm (zone of drag being). The results of the characterization of the inhibitory Zones P using the bacteria Staphylococcus aureussebesar2,076 ± 0.083 mm (weak inhibitory zone) and Escherichia coli amount of 3, 11 ± 0.107 mm (zone of drag being). Papaya leaf extract is more effective in providing the activity of inhibitory bacteria Escherichia coli than Staphylococcus aureus.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Carica papaya l., papaya leaves, antimicrobial, micro particles, encapsulation, gelasi Ionic, chitosan, sodium alginate
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 09 Aug 2019 05:24
Last Modified: 09 Aug 2019 05:24
URI: http://repository.unsri.ac.id/id/eprint/3328

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