Sinulingga, Sadakata (2018) Peer Review_Efficacy of Morinda citrifolia Fruit Extract to Increase Insulin Synthesis in Wistar Rats-Induced Diabetics. Research Journal of Pharmaceutical, Biological and Chemical Sciences. (Submitted)
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Efficacy of Morinda citrifolia Fruit Extract to Increase Insulin Synthesis in Wistar Rats-Induced Diabetics.pdf Download (1MB) | Preview |
Abstract
The use of secretagogues agent as therapeutic modality has considerably frequent side effects. Hence, the use of natural materials as a new therapeutic modality is growing rapidly due to the efficacy, minimal side effects, and its economical property. Morinda citrifolia (Rubiaceae) is originally discovered in Asia, Australia, Polynesia and The Pacific, and identified in Indonesia as Mengkudu. This plant is common to be utilized traditionally in overcoming various health problems, one of which is diabetes mellitus. This study aimed to determine the efficacy of Morinda citrifolia fruit extract to increase insulin synthesis in white rats diabetic model. Morinda citrifolia fruits extraction process was performed with maceration technique using ethanol solvent (1:10), followed by the filtration and evaporation process. Male white rats were kept in a room that had been conditioned and acclimatized prior to be used in the study. Rats were induced to sustain diabetes mellitus with streptozotocin. Administration of studied materials was carried out for 7 days in several doses. Plasma glucose and plasma insulin measurement was performed afterward. Statistical analysis was conducted using SPSS 18 with bivariate analysis of T-test and multivariate analysis of Bonferroni post-hoc test. The administration of the extract at doses of 10, 20, 40 mg/kgBW, and glibenclamide for 7 days resulted in significant weight gain, lower fasting plasma glucose levels, and elevated insulin secretion compared to negative control. Morinda citrifolia fruit extract was effective in lowering plasma glucose levels by increasing insulin secretion in white rats diabetic model.
| Item Type: | Other |
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| Subjects: | |
| Divisions: | 04-Faculty of Medicine > 11201-Medicine (S1) |
| Depositing User: | Drs Sadakata Sinulingga |
| Date Deposited: | 17 Nov 2020 08:40 |
| Last Modified: | 17 Nov 2020 08:40 |
| URI: | http://repository.unsri.ac.id/id/eprint/37531 |
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