Fitrya, Fitrya (2020) Ethanol extract of Parkia speciosa Hassk. loaded transfersome: Characterization and optimization. Journal of Pharmacy & Pharmacognosy Research, 8 (3). pp. 167-176. ISSN 0719-4250
Preview |
Text
JPPRes Home+lengkap.pdf - Published Version Download (2MB) | Preview |
Abstract
Context: Parkia speciosa is a species which contains hydrophilic compounds such as flavonoids and phenolics. These compounds are difficult to penetrate lipophilic biological membranes. Transfersome is a targeted dosage form that can overcome the limitations of phytomedicine. Aims: To improve the ability of extracts to penetrate biological membranes. Methods: Transfersome was formulated with soya lecithin and Tween-80 as independent variables using factorial design 32. The influence of factor compositions and factor interactions on transfersome characteristics was observed based on efficiency absorption percentage (%EE), polydispersity index (PDI), stability, and pH. Results: Analysis with DX® 10 produced optimum formula with 0.85 g of lecithin and 0.15 g of tween-80. The optimum formula characteristics’ results analysis was as follows: %EE (91.6884 ± 0.0261%), particle size (495.6 nm), PDI (0.484), and zeta potential (-21.4 mV) and spherical vesicle shape. Stability testing showed that transfersome was more stable compared to the pure extracts. Diffused transfersome percentage (6.6253 ± 0.5817 %) on the minute 360 was better than the pure extracts (1.8800 ± 0.0187 %). Compartmental transfersome analysis with WinSAAMTM software followed lag compartment model (p<0.05). Interaction test using FTIR showed that there was no chemical interaction between extract and excipients. Conclusions: The finding result in this investigation shows that transfersome loaded with ethanol extract of Parkia speciosa is more stable and more easily diffused compare to the pure extract.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | factorial design; Parkia speciosa Hassk; soya lecithin; transfersome; Tween-80. |
| Subjects: | #3 Repository of Lecturer Academic Credit Systems (TPAK) > Hak Atas Kekayaan Intelektual (HAKI)-PATENT |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1) |
| Depositing User: | M.Si, Apt. Fitrya Fitrya |
| Date Deposited: | 05 Jan 2021 07:12 |
| Last Modified: | 05 Jan 2021 07:12 |
| URI: | http://repository.unsri.ac.id/id/eprint/38737 |
Actions (login required)
 |
View Item |