Sriyanti, Ida and Edikresnha, Dhewa and Rahma, Annisa and Munir, Muhammad Miftahul and Rachmawati, Heni and Khairurrijal, Khairurrijal (2018) Mangosteen pericarp extract embedded in electrospun PVP nanofiber mats: physicochemical properties and release mechanism of α-mangostin. International Journal of Nanomedicine, 2018 (13). pp. 4927-4941. ISSN 11782013/ 11769114
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Abstract
Background: α-Mangostin is a major active compound of mangosteen (Garcinia mangostana L.) pericarp extract (MPE) that has potent antioxidant activity. Unfortunately, its poor aqueous solubility limits its therapeutic application. Purpose: This paper reports a promising approach to improve the clinical use of this substance through electrospinning technique. Methods: Polyvinylpyrrolidone (PVP) was explored as a hydrophilic matrix to carry α-mangostin in MPE. Physicochemical properties of MPE:PVP nanofibers with various extract-to-polymer ratios were studied, including morphology, size, crystallinity, chemical interaction, and thermal behavior. Antioxidant activity and the release of α-mangostin, as the chemical marker of MPE, from the resulting fibers were investigated. Results: It was obtained that the MPE:PVP nanofiber mats were flat, bead-free, and in a size range of 387–586 nm. Peak shifts in Fourier-transform infrared spectra of PVP in the presence of MPE suggested hydrogen bond formation between MPE and PVP. The differential scanning calorimetric study revealed a noticeable endothermic event at 119°C in MPE:PVP nanofibers, indicating vaporization of moisture residue. This confirmed hygroscopic property of PVP. The absence of crystalline peaks of MPE at 2θ of 5.99°, 11.62°, and 13.01° in the X-ray diffraction patterns of electrospun MPE:PVP nanofibers showed amorphization of MPE by PVP after being electrospun. The radical scavenging activity of MPE:PVP nanofibers exhibited lower IC50 value (55–67 µg/mL) in comparison with pure MPE (69 µg/mL). The PVP:MPE nanofibers tremendously increased the antioxidant activity of α-mangostin as well as its release rate. Applying high voltage in electrospinning process did not destroy the chemical structure of α-mangostin as indicated by retained in vitro antioxidant activity. The release rate of α-mangostin significantly increased from 35% to over 90% in 60 minutes. The release of α-mangostin from MPE:PVP nanofibers was dependent on α-mangostin concentration and particle size, as confirmed by the first-order kinetic model as well as the Hixson–Crowell kinetic model.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | α-mangostin, mangosteen, polyvinylpyrrolidone, electrospinning, nanofiber, drug delivery system |
| Subjects: | L Education > L Education (General) > L7-991 Education (General) Q Science > QC Physics > QC1-999 Physics R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | 06-Faculty of Education and Educational Science > 84103-Physics Education (S2) |
| Depositing User: | Dr Ida Sriyanti, M.Si |
| Date Deposited: | 01 Mar 2021 03:54 |
| Last Modified: | 01 Mar 2021 03:54 |
| URI: | http://repository.unsri.ac.id/id/eprint/39812 |
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