Setiawan, Arum and Hanum, Laila and Wardoyo, Elvi Rusmiyanto (2017) Hypolipidemic Activity of Mundu Fruit (Garcinia dulcis (Roxb.) Kurz) in White Rat (Rattus norvegicus L.). Proceeding of International Conference on Biodiversity for Sustainable Industries (1). pp. 88-93. ISSN ISBN:978-602-61830-0-2
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2.8. HYPOLIPIDEMIC ACTIVITY OF MUNDU FRUIT (Garcinia dulcis) Proceeding.pdf Download (2MB) | Preview |
Abstract
The objectives of this research were to identify compound and hypolipidemic activity of Garcinia dulcis fruit on lyphoprotein profile and triglyseride in white rat hyperlipidemic. These studies using Garcinia dulcis fruit from Banyuasin, South Sumatra. In this observation, 30 male white rat from Laboratory and Research Institute for Integrated Testing, Gadjah Mada University, 2 months old were used and divided into five groups randomly. The first group was given high cholesterol and lipid diet, as a normal group. The second group was given high cholesterol, lipid diet and simvastatin 3,6 mg/kg bow/day dosage, as a simvastatin group. The third, fourth and fifth groups was given high cholesterol, lipid diet and upper isolate 1.8; 2.7 and 3.6 mg/kg bow/day dosage. Total cholestrol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and triglyseride contains using spectrophotometry method, were observed 1 and 30 days. The result of the hypolipidemic activity showed that phenolic compound treatment doses of 3.6 mg/kg bw and simvastatin lowers lyphoprotein and triglyceride levels, significantly different compared with the treatment dose of 2.7 and 1.8 mg/kg bw. The purification of compound was done by recrystalitation with CH2Cl2. The structure was elucidated by spectroscopic methods with UV, IR, 1H-NMR and 13C-NMR. Based on spectral data of LC-ESI-ToF-MS showed that the compound was dulcisxanthone.
| Item Type: | Article |
|---|---|
| Additional Information: | Proceeding of International Conference on Biodiversity for Sustainable Industries |
| Subjects: | Q Science > QP Physiology Q Science > QP Physiology > QP(901)-(981) Experimental pharmacology |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 46201-Biology (S1) |
| Depositing User: | Dr Arum Setiawan |
| Date Deposited: | 01 Feb 2021 23:57 |
| Last Modified: | 01 Feb 2021 23:57 |
| URI: | http://repository.unsri.ac.id/id/eprint/41626 |
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