Nindela, Rini (2018) Elevated Monocyte Levels in Peripheral Circulation associated with Pneumonia in Acute Ischemic Stroke Patients at Dr. Moh. Hoesin General Hospital. In: Asia Pacific Stroke Conference 2018, 6-9 September 2018, Jakarta.
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Abstract
Background and Objectives: One of the complications of acute ischemic stroke that contributes to high mortality and morbidity is infection with reported incidence varying from 5% to 65%. Pneumonia (7-22%) is the most common post-stroke infection and also the main cause of death in stroke patients. The major component in ischemic stroke pathobiology is inflammation. The number of inflammatory cells—one of them is monocyte—increases at the site of injury. Previous studies have shown that increased monocyte counts are related with stroke-associated infection (SAI). The severity of stroke is also known to increase the risk of pneumonia. This study aimed to determine the relationship between the number of monocytes in the peripheral blood and the severity of stroke with the incidence of pneumonia in patients with acute ischemic stroke. Methods: This study was an analytic study with cohort design. Blood samples were taken when patients were admitted to the hospital. The number of monocytes was obtained from the multiplication of the percentage of monocytes with the total number of leukocytes. The severity of stroke was determined by the NIHSS score and divided into mild-to-moderate stroke and severe stroke. Stroke patients who met the inclusion-exclusion criteria were then observed for pneumonia during the hospitalization. Results: From 22 subjects of the study, the incidence of pneumonia was 22.7%. The severity of stroke was not related to the incidence of pneumonia (Fisher exact test: p = 0.311; OR = 5.71). Nevertheless, the incidence of pneumonia was higher in severe stroke group (18.2%) than in mild-to-moderate stroke group (4.5%). Median of monocyte value was 827.50/mm3 with a minimum value of 384/mm3 and a maximum value of 1688/mm3. Cut-off point of monocyte was at 1028/mm3 with 80% sensitivity, 88.2% specificity and AUC 90.6% (95% CI: 0% -100%). The number of monocytes >1028/mm3 was associated with the incidence of pneumonia (Fisher exact test: p = 0.009; OR = 30.0, 95% CI: 2.1-421.1). Conclusion: Greater number of monocytes in peripheral blood increases the risk of pneumonia in patients with acute ischemic stroke. Keywords: acute ischemic stroke, monocyte, pneumonia
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RZ Other systems of medicine > RZ201-999 Other systems of medicine |
| Divisions: | 04-Faculty of Medicine > 11703-Neurology (Sp |
| Depositing User: | dr Rini Nindela |
| Date Deposited: | 11 Mar 2021 09:41 |
| Last Modified: | 11 Mar 2021 09:41 |
| URI: | http://repository.unsri.ac.id/id/eprint/43632 |
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