UJI AKTIVITAS PENINGKATAN DAYA INGAT EKSTRAK ETANOL RIMPANG BANGLE (Zingiber cassumunar Roxb.) TERHADAP MENCIT JANTAN PUTIH GALUR SWISS-WEBSTER

HERYANA, UMMI and Herlina, Herlina and Solihah, Indah (2018) UJI AKTIVITAS PENINGKATAN DAYA INGAT EKSTRAK ETANOL RIMPANG BANGLE (Zingiber cassumunar Roxb.) TERHADAP MENCIT JANTAN PUTIH GALUR SWISS-WEBSTER. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061281419036_0003077102_0008038802_01_front_ref.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061281419036_0003077102_0008038802_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (463kB) | Request a copy
	Text RAMA_48201_08061281419036_0003077102_0008038802_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (217kB) | Request a copy
	Text RAMA_48201_08061281419036_0003077102_0008038802_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (348kB) | Request a copy
	Text RAMA_48201_08061281419036_0003077102_0008038802_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (31kB) | Request a copy
	Text RAMA_48201_08061281419036_0003077102_0008038802_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (214kB) | Request a copy
	Text RAMA_48201_08061281419036_0003077102_0008038802_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

A study have been done to investigate the effect of ethanol extract of bangle rhizome (Zingiber cassumunar Roxb.) on memory enhancement of white male mice Swiss-Webster strain using passive avoidance test method. Bangle rhizome contain triterpenoid and phenolic compounds that potentially improve the function of memory. This research conducted include characterization of extract, determination of extract memory enhancement activity by calculating parameters of long retention and determination the best doses of extract to improve memory. Mice were used as animal models which were divided into 6 groups, normal group, positive control with piracetam 500 mg/kgBW, negative control with sodium CMC 1% and 3 groups of bangle rhizome ethanol extract at doses 120, 240 and 480 mg/kgBW orally. All treatment groups were induced with scopolamine 3 mg/kgBW intraperitoneally except normal group. Data were analyzed by one way ANOVA and LSD test with 95% confidence level. The result of extract characterization showed water content 7.769%, shrinkage drying 8.473%, water soluble content 5.500%, ethanol soluble extract 89.500%, total ash content 0.922% and acid unsaturated ash content 0.212%. This research showed that average of long retention for positive control 570.700 seconds, negative control 178.320 seconds and 3 treatment groups (120, 240, and 480 mg/kgBW) were 588.525, 588.530 and 589.800 seconds. In conclusion, ethanol extract of bangle rhizome able to improve mice memory. Ethanol extract of bangle rhizome at dose 480 mg/kgBW showed the best effect to improve memory because it had the greatest long retention.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	bangle rhizome, piracetam, scopolamine, memory, passive avoidance test
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	16 Aug 2019 05:25
Last Modified:	16 Aug 2019 05:25
URI:	http://repository.unsri.ac.id/id/eprint/4449

Actions (login required)

View Item