UJI EFEK EKSTRAK ETANOL DAUN JARAK PAGAR (JATROPHA CURCAS L.) SEBAGAI KOAGULAN PADA TIKUS GALUR WISTAR (RATTUS NORVEGICUS)

APRIANI S, ROSA and K, Trisnawaty and Parisa, Nita (2021) UJI EFEK EKSTRAK ETANOL DAUN JARAK PAGAR (JATROPHA CURCAS L.) SEBAGAI KOAGULAN PADA TIKUS GALUR WISTAR (RATTUS NORVEGICUS). Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Coagulants or hemostatic agents are substances that can stop bleeding through hemostatic and coagulation processes. The use of herbal plants as medicine to stop bleeding has been used since ancient times, including jatropha leaf. Aim: To determine the effect of Jatropha leaves ethanol extract in reducing bleeding time and clotting time. Knowing the optimum concentration or dose of Jatropha leaves ethanol extract in reducing bleeding time and clotting time seen from different concentrations. Method: This type of research is true experimental with pretest-posttest control group design. A total of 30 male wistar rats were divided into 5 treatment groups. Group I ethanol extract of jatropha leaves 3.5%, group II ethanol extract of jatropha leaf 7%, group III ethanol extract of jatropha leaf 14%, group IV negative control Cmc-Na, group V positive control tranexamic acid. The rats were cut of the tail using minor surgical scissors and measuring using stopwatch. Measuring the clotting time of rats, the blood was drawn 0,5 ml in the eye and then inserted into the Effendov tube, the stopwatch was run, and the blood in the tube was tilted until clot formation was formed, then the stopwatch was stopped and the results were recorded. Results: The mean bleeding time and clotting time of all groups decreased significantly compared to before treatment in all groups(p <0.05) except in the negative control group. The optimum concentration of Jatropha leaf ethanol extract which has the effect as a coagulant or hemostatic agent on bleeding time and clotting time is 7% Conclusion: The ethanol extract of Jatropha leaf has a effect as a coagulant, more concentration makes more effect as coagulant. Key words: Jatropha leaf ethanol extract, coagulant, hemostatic agent, bleeding time, clotting time, Wistar rat.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ekstrak etanol daun jarak pagar, koagulan, agen hemostatik, bleeding time, clotting time, tikus wistar
Subjects:	R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions:	04-Faculty of Medicine > 12201-Dentistry (S1)
Depositing User:	Users 11549 not found.
Date Deposited:	01 Apr 2021 06:20
Last Modified:	01 Apr 2021 06:20
URI:	http://repository.unsri.ac.id/id/eprint/44676

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