ISOLASI SENYAWA FLAVONOID DARI FRAKSI ETIL ASETAT DAUN Ludwigia leptocarpa DAN UJI SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P-388

SAPUTRI, ARIYANTI and Ferlinahayati, Ferlinahayati and Eliza, Eliza (2018) ISOLASI SENYAWA FLAVONOID DARI FRAKSI ETIL ASETAT DAUN Ludwigia leptocarpa DAN UJI SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P-388. Undergraduate thesis, Sriwijaya University.

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Abstract

The isolation of flavonoid from Ludwigia leptocarpa leaves and its cytotoxic assay on murine leukemia P-388 cells had been done. The isolation was conducted by maceration method using methanol as the solvent, followed by fracination using n-heksana and ethyl acetate. Separation and purification of ethyl acetate fraction using several techniques of chromatographic. The isolated compound was a yellow solid (14,5 mg) with melting point 285 oC (decomposed). Based on spectral data including UV, IR, 1H-NMR, 13C-NMR and compared with a reference suggested that the isolated compound was flavonoid type flavonol namely quercetine. This compound was active on cytotoxic assay against murine leukemia P-388 cells with IC50 3,98 μg/mL.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ludwigia leptocarpa, flavonoid, quercetine, cytotoxic, murine leukemia P-388 cell
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	20 Aug 2019 02:30
Last Modified:	20 Aug 2019 02:30
URI:	http://repository.unsri.ac.id/id/eprint/4583

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