ISOLASI SENYAWA FENOLIK SEDERHANA DARI FRAKSI ETIL ASETAT BATANG Ludwigia Leptocarpa DAN UJI SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P-388

HARYATI, WINDA and Ferlinahayati, Ferlinahayati and Eliza, Eliza (2018) ISOLASI SENYAWA FENOLIK SEDERHANA DARI FRAKSI ETIL ASETAT BATANG Ludwigia Leptocarpa DAN UJI SITOTOKSIK TERHADAP SEL MURIN LEUKEMIA P-388. Undergraduate thesis, Sriwijaya University.

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Abstract

L. leptocarpa is a semi-aquatic plant in the Onagraceae family. The main compound of this plant are phenolic , steroid, triterpenoid derivatives. The goals of the research were to isolate and identificate phenolic compound from ethyl acetate fraction of L. leptocarpa stem and evaluate its toxicity againts murine leukemia P-388 cell. Isolation was conducted by maceration method with methanol as the solvent followed by separation and purification using several chromatographic techniques. The isolate compound was obtained as yellowish white solid as much as 27.3 mg with melting point 194.5-195.6 oC. The structure of the isolated compound was determined based on UV, IR, 1H-NMR, and 13C-NMR specrum as well as comparison with literature. Based on those spectral data, the isolated compound was methyl gallate. The isolated compound was very active cytotoxic against murine leukemia P-388 cell with IC50 1.06 μg/mL.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Phenolic, L. Leptocarpa, methyl gallate, cytotoxic
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry Q Science > QD Chemistry > QD71-142 Analytical chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	20 Aug 2019 03:08
Last Modified:	20 Aug 2019 03:08
URI:	http://repository.unsri.ac.id/id/eprint/4587

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