UJI SITOTOKSIK PERASAN DAN BERBAGAI VARIASI EKSTRAK BUAH PARE (Momordica charantia Linn.) DENGAN METODE Brine Shrimp Lethality Test (BSLT)

HANIK, UMI and Herlina, Herlina and Solihah, Indah (2018) UJI SITOTOKSIK PERASAN DAN BERBAGAI VARIASI EKSTRAK BUAH PARE (Momordica charantia Linn.) DENGAN METODE Brine Shrimp Lethality Test (BSLT). Undergraduate thesis, Sriwijaya University.

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Abstract

Pare fruits (Momordica charantia Linn.) had been known to contain saponins, flavonoids, alkaloids, steroid dan triterpenoids component that could act as a cytotoxic agent. This study aimed to determine find cytotoxic activity of ethanol, ethyl acetate, and n-hexane extract and juice of pare. The cytotoxic test of each extract was carried out using the BSLT method (Brine Shrimp Lethality Test), this method is often used as a preliminary screening of the active compounds contained in plant extracts as anticancer. The cytotoxic activity test was conducted using various concentrations of 31,25; 62,5; 125; 250, dan 500 ppm with control solution (artificial seawater). The resulting LC50 values in each extract using the Microsoft Excel probit analysis program are respectively 294,440 μg/mL; 445,090 μg/mL; 937,728 μg/mL and 484,269 μg/mL. Physical and chemical characteristics of ethanol extract have organoleptis with brown color, thick and sweet smell typical, water soluble and ethanol 80% and 26,315%; Bj 1,011 ± 0,001 g/mL; water contant 8,585% ± 0,589; total ash contant 13,229% ± 1,441; and ash content is not soluble acid 1,556% ± 0,059. Statistical analysis with two way annova showed a significant difference in each extract, with significance value of 0,000 (p<0,05). The results of this study indicate that the highest cytotoxic activity is found in ethanol extract with LC50 value of 294,44 μg/mL which is classified as low toxic.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Pare fruits, BSLT, ethanol extract, physical and chemical characteristics, low toxic
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	20 Aug 2019 05:05
Last Modified:	20 Aug 2019 05:05
URI:	http://repository.unsri.ac.id/id/eprint/4628

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