STANDARDISASI DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK N-HEKSAN, ETIL ASETAT DAN ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP Escherichia coli DAN Staphylococcus aureus

NURAKELA, SHENI FUTRIA and Untari, Budi and Fitrya, Fitrya (2018) STANDARDISASI DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK N-HEKSAN, ETIL ASETAT DAN ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP Escherichia coli DAN Staphylococcus aureus. Undergraduate thesis, Sriwijaya University.

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Abstract

Papaya (Carica papaya Linn.) is categorized in Caricaceae family. This plant was empirically used as antidiarrhea and as remedy for skin diseases such as acnes. Phytochemicals screening result indicates that papaya leaves contain alkaloids, tannins, flavonoids and saponins. This study was conducted to determine the antibacterial activity of n hexane, ethyl acetate and ethanol extract also to determine the value of bacterial inhibiton zone of papaya leaves extract. The parameter of this study includes concentration test of papaya leaves extract by 5, 10, and 15% concentrate, minimum inhibitory concentration (MIC) against Escherichia coli and Staphylococcus aureus after macerated with n hexane, ethyl acetate, and 96% ethanol as solvents, also the standardization parameter value of the extract. This study is using agar diffusion method with paper discs for testing antibacterial activity. Extract with the smallest MIC was selected to be standardized. The standardization test includes specific and non specific parameter. The minimum inhibitory concentration (MIC) of ethanol and ethyl acetate extract i.e 2% and 5%. The result of the standardization of ethanol extract through a specific parameter test showed that the extract thick with less fluid, greenish black, typical smell, and the taste slightly bitter. Content of extract soluble in water of 25,37% ± 20,20% and content of extract soluble in ethanol of 31,92% ± 26,85%. Meanwhile, the result through a non specific parameter test of ethanol showed that the total ash content of 6,66% ± 3,78%, ash content insoluble in acid 4,3% ± 3,8%, drying shrink age of 32,66% ± 12,25%, and a specific gravity of 1,00% ± 0,02%.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Carica papaya Linn., antibactery, standardization, n hexane, ethyl acetate, ethanol
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 20 Aug 2019 05:34
Last Modified: 20 Aug 2019 05:34
URI: http://repository.unsri.ac.id/id/eprint/4632

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