UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL KULIT PETAI (Parkia speciosa Hassk.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4

SETYARINI, DYAH AYU and Fitrya, Fitrya and Amriani, Annisa (2018) UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL KULIT PETAI (Parkia speciosa Hassk.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI CCl4. Undergraduate thesis, Sriwijaya University.

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Abstract

Petai’s peels (Parcia speciosa Hassk.) is a medicinal plant that used as traditional medicine. Petai’s peels contains some secondary metabolites which have potency to hepatoprotector. Study purposed to know hepatoprotector effect of ethanol extract of petai’s peels through measurement of SGPT, SGOT and macroscopic description of liver organ in Male Wistar albino rats. Rats were divided into 6 groups, normal control group (sodium CMC 1%), negative control group (CCl4 0.5 mL/kgBW), positive control group (silymarin 200 mg/kgBW), and group test of ethanol extract petai’s peels doses 100, 200, and 400 mg/kgBW. Rats were given appropriate treatment groups for 14 days, then induced CCl4 on 15th. Rats was killed and conducted macroscopic observation of liver organ. The result showed ethanol extract petai’s peels effective as hepatoprotector with % hepatoprotector effect (%EH) for SGPT and SGOT of group I is 39.972 and 39.548%, group II is 65.089 and 46.616%, and group III is 92.790 and 82.765%. Macroscopic description of liver organ of group test some with criteria of normal liver. The result showed that ethanol extract of petai’s peels has hepatoprotector activity and significantly different from negative control (p<0,05). Based on the percentage relation hepatoprotector effect to dose, then the effective dose 50 (ED50) value of ethanol extract petai’s peels of SGPT and SGOT is 140.471 and 191.476 mg/kgBW. Dose 400 mg/kgBW gave better hepatoprotector activity than dose 100 and 200 mg/kgBW. Hepatoprotector activity shown by the reduction of SGPT and SGOT levels and also macroscopic description of liver some with criteria of normal liver.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Parkia speciosa Hassk., hepatoprotector, SGPT, SGOT, macroscopic liver
Subjects:	R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	20 Aug 2019 08:51
Last Modified:	20 Aug 2019 08:51
URI:	http://repository.unsri.ac.id/id/eprint/4657

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