PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) DAN STABILIZER POLY(VINYL ALCOHOL) PEMBAWA ROKSITROMISIN DENGAN VARIASI JUMLAH ROKSITROMISIN

MUSTIKA, INTAN SRI and Mardiyanto, Mardiyanto and Amriani, Annisa (2018) PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY(LACTIC-CO-GLYCOLIC ACID) DAN STABILIZER POLY(VINYL ALCOHOL) PEMBAWA ROKSITROMISIN DENGAN VARIASI JUMLAH ROKSITROMISIN. Undergraduate thesis, Sriwijaya University.

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Abstract

Development of antibiotic preparation in submicroscopic form which expected to reduce the therapeutic dose, which transport and protect drug molecules from degradation and deliver the drug to target cells to maintain activity on the infection site. Roxithromycin classified into Biopharmaceutics Classification System (BCS) class II which shows that low solubility in water but has high permeability. Low solubility causes a decrease bioavailability so that pharmacological effects are not achieved perfectly. Preparation was done by single emulsion solvent evaporation method using polymer Poly(Lactic-co-Glycolic Acid) (PLGA) and stabilizer Poly(Vinyl Alcohol) (PVA). Quantity of roxithromycin was varied into three formulas which are ; 50 mg for formula 1, 100 mg for formula 2 and 150 mg for the formula 3. The percentage of encapsulation efficiency (%EE) obtained for the three formulas were 89.861 ± 0.131% (formula 1 ), 90.688 ± 0.043% (formula 2), and 89.755 ± 0.272% (formula 3). The higher the %EE value indicates more encapsulated roxithromycin in formula 2. Formula 2 is characterized on the physical properties using Particle Size Analyzer (PSA) to obtain the results for formula 2, particle diameter was 391.4 nm, size distribution (PDI) was 0.333, and zeta potential was 0.5 mV. Physical stability testing of pH variation for 14 days showed that formula 2 was unstable at pH 7.4. The dissolution analysis performed on submicron of PLGA-roxithromycin particles, pure roxithromycin powder and conventional tablet of roxithromycin showed the result of dissolution efficiency (DE) values were 76.019 ± 0.178%, 41.378 ± 0.004%, and 43.963 ± 0.023% respectively. The rate and mechanism of submicron release of PLGAroxithromycin was following the first order and the Higuchi model, which could be concluded that the submicron optimum formula has better dissolution kinetic rate.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Roxithromycin, PLGA, PVA, submicron particle, dissolution
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	19 Jul 2019 09:24
Last Modified:	19 Jul 2019 09:24
URI:	http://repository.unsri.ac.id/id/eprint/471

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