Fitrya, Fitrya (2020) Optimization and characterization of solid lipid nanoparticles carrier ethanol extracts of Parkia speciosa pod. Medicinal Plant, 12 (2). pp. 301-308. ISSN 09754261, 09756892
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Abstract
Parkia speciosa (Petai) contains phenolic and flavonoid components as an antioxidant. This function is not optimal because the biological membrane is lipophilic while the compounds is hydrophilic. The objective of this study was to prepare the ethanol extract of Parkia speciosa into Solid Lipid Nanoparticles (SLN) as an effort to overcome the difficulty of penetration of active compounds through biological membranes. The optimum formula was designed using factorial design 23. Surfactant concentration, preparation temperature, and stirring speed were independent variable that act as factors. The influence of these factors on characteristics of SLN was analyzed by using Design Expert®10 (Stat-Ease Inc.) software. The test results showed that the optimum formula was obtained at a tween-80 concentration of 0.704 mL, a preparation temperature of 60oC and a stirring speed of 1000 rpm. The optimum formula characteristic was % EE 88.81±0.06%, particle size of 393.8 nm, polydispersity index (PDI) of 0,421 and zeta potential of -1.7 mV, respectively. The percentage of diffused SLN was better (9.83±0.011%) than the percentage of diffused extract (4.48±0.022%). The results showed that the ability of SLN to penetrate membrane was greater than the extract but SLN showed instability due to the formation of aggregates in storage. The compartmental analysis with WinSAAMTM software revealed the optimum formula following the compartment lag model with a p-value <0.05. Keywords: Petai, solid lipid nanoparticles, surfactant, temperature
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Petai, solid lipid nanoparticles, surfactant, temperature |
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1) |
| Depositing User: | M.Si, Apt. Fitrya Fitrya |
| Date Deposited: | 17 Jun 2021 02:40 |
| Last Modified: | 17 Jun 2021 02:40 |
| URI: | http://repository.unsri.ac.id/id/eprint/48066 |
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