UJI EFEK ANTIOKSIDAN ESTRAK ETANOL DAUN MATOA (Pometia pinnata) TERHADAP KADAR MALONDIALDEHID MENCIT YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4)

ANGGRESTINA, IRMA and Fitrya, Fitrya and Novita, Rennie Puspa (2018) UJI EFEK ANTIOKSIDAN ESTRAK ETANOL DAUN MATOA (Pometia pinnata) TERHADAP KADAR MALONDIALDEHID MENCIT YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4). Undergraduate thesis, Sriwijaya University.

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Abstract

Matoa leaves (Pometia pinnata) contains some secondary metabolites which have potency to block of free radicals. The study purposed to know effect of ethanol extract matoa’s leaves as an antioxidant that prevents liver damage by looking at the levels of malondialdehyde (MDA) in mice white males with thiobarbituric acid reactive substance (TBARS) methode. Mice were divided into 6 groups, normal control group (sodium CMC 1%) negative control group (sodium CMC 1%), positive control group (vitamin E 100 mg/kgBW), and treatment groups I, II, and III (ethanol extract matoa’s leaves with dosage 200, 400 and 600 mg/kgBW). Each group induced by carbon tetrachloride (CCl4) on the seventh day, then conducted measurements the level of MDA on the eighth day. The result showed ethanol extract matoa’s leaves inhibits free radicals with average MDA levels of group I, II, and III is 1.19 ± 0.24; 1.02 ± 0.34 and 0.67 ± 0.15 nmol/mL. The result showed that ethanol extract of matoa’s leaves has antioxidant activity and no significant differences (p>0,05) from normal control with a level of 0.33 ± 0.21 nmol/mL and positive control with a level of 0.38 ± 0.18 nmol/mL, but significantly different (p<0.05) from negative control with a level of 2.99 ± 1.53 nmol/mL. Dosage 600 mg/kgBW of ethanol extracts matoa’s leaves has the best antioxidant effects that could potentially prevents liver damage. The results of the characterization of the extract according the requrements of MMI for levels of ethanol soluble extract is 63.17% ± 1.89; levels of water soluble extract is 24.17% ± 1.76; shrinkage drying is 9.06% ± 0.63; water content is 8.24% ± 0.48 and total ash content is 2.07% ±0.21.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Pometia pinnata, antioxidant, TBARS, malondialdehyde
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 28 Aug 2019 02:35
Last Modified: 28 Aug 2019 02:35
URI: http://repository.unsri.ac.id/id/eprint/4943

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