Indrajaya, Taufik (2021) The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients (Peer Review). Fakultas Kedokteran, Universitas Sriwijaya, International Journal of Nephrology. (Unpublished)
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Abstract
Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney diseasemineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. ,is study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. ,e level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. ,e median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r � 0.449; p � 0.001) was observed. During multivariate analysis with linear regression, triglyceride (p � 0.049), phosphate (p � 0.005), and activin A (p � 0.020) serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT
| Item Type: | Other |
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| Subjects: | |
| Divisions: | 04-Faculty of Medicine > 11802-Internal Medicine (Sp |
| Depositing User: | Dr.dr. Taufik Indrajaya |
| Date Deposited: | 13 Jul 2021 06:51 |
| Last Modified: | 13 Jul 2021 06:51 |
| URI: | http://repository.unsri.ac.id/id/eprint/49431 |
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