PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY-(LACTIC-CO-GLYCOLIC ACID) PEMBAWA EKSTRAK ETANOL DAUN KIRINYUH (Chromolaena odorata L.)

PRAVITASARI, DEVI OKTAVIANI and Mardiyanto, Mardiyanto and Solihah, Indah (2021) PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL POLY-(LACTIC-CO-GLYCOLIC ACID) PEMBAWA EKSTRAK ETANOL DAUN KIRINYUH (Chromolaena odorata L.). Undergraduate thesis, Sriwijaya University.

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Abstract

Preparasi ekstrak etanol daun kirinyuh ke dalam submikro partikel bertujuan untuk mengatasi permasalahan sifat senyawa flavonoid yang terkandung didalam ekstrak yaitu termolabil serta meningkatkan kemampuan penghantaran pada kulit. Diperoleh kadar flavonoid total yang terkandung dalam ekstrak sebesar 95,204±3,568 mg/g. Metode emulsion solvent evaporation digunakan dalam preparasi ekstrak yang terenkapsulasi oleh polimer PLGA (poly-lactic-co-glycolic acid) dan stabilizer PVA (polyvynil alcohol). Konsentrasi PVA divariasikan untuk mengetahui pengaruhnya terhadap stabilisasi submikro partikel. Proporsi komponen PVA yang digunakan yaitu 50 mg, 60 mg dan 70 mg serta diperoleh nilai respon %EE berturut-turut 90,829%; 64,919%; dan 43,287%. Hasil karakterisasi submikro partikel formula terbaik (F1) menunjukkan nilai diameter partikel, PDI, dan zeta potensial berturut-turut sebesar 225,3±2,04 nm; 0,242±0,01; dan -12,4±1,3 mV. Hasil uji stabilitas formula terbaik menggunakan metode heating cooling cycle menunjukkan penurunan kadar sebesar 1,539±0,1%, penurunan pH sebesar 0,04±0,433, serta memiliki organoleptis berbau khas ekstrak, warna kuning tidak berubah, tetapi terbentuk sedikit partikel melayang.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun Kirinyuh, flavonoid, PLGA, PVA, Emulsion solvent evaporation
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Devi Oktaviani Pravitasari
Date Deposited:	04 Aug 2021 04:44
Last Modified:	04 Aug 2021 04:44
URI:	http://repository.unsri.ac.id/id/eprint/51202

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