ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER DARI FRAKSI METANOL DAUN TUMBUHAN RUKAM (FLACOURTIA RUKAM)

NABILAH, RIFDAH and Muharni, Muharni and Fitrya, Fitrya (2021) ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER DARI FRAKSI METANOL DAUN TUMBUHAN RUKAM (FLACOURTIA RUKAM). Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061181621018.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061181621018_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
Preview	Text RAMA_48201_08061181621018_0004036903_0010127203_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (2MB) | Preview
	Text RAMA_48201_08061181621018_0004036903_0010127203_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061181621018_0004036903_0010127203_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (746kB) | Request a copy
	Text RAMA_48201_08061181621018_0004036903_0010127203_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061181621018_0004036903_0010127203_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (610kB) | Request a copy
	Text RAMA_48201_08061181621018_0004036903_0010127203_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (741kB) | Request a copy
	Text RAMA_48201_08061181621018_0004036903_0010127203_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Flacourtia rukam is a plant that has been used traditionally, one of its benefits as a treatment for diarrhea and dysentry. The aims of this study to isolated secondary metabolites from the methanol fraction of rukam leaves and their antibacterial activity test against Salmonella typhi and Shigella dysentriae. This research was started by maseration method using solvent with increasing polarity. Separation and purification were done by chromatography methods. The structure of this compound was determined base on spectroscopic data such as IR, 1H-NMR, 13C-NMR and comparison with the reported data. The antibacteria activity of the isolated compound was tested by paper disc difusion method and minimum inhibitory concentration (MIC) value was determined by the micro dilution method using the 96-well plates. A Pure compound that was isolated from white crystal (17 mg). Based on spectroscopy data analysis and compared with data from the literature, the isolated compound belonged to triterpenoid group that is lupeol with molecule formula C30H50O. The isolated compound show antibacterial activity against Salmonella typhi and Shigella dysentriae with an MIC value of 100 ppm, inclued in the moderate category. The compound is reported here for the first time from F. rukam.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antibakteri, Flacourtia rukam, Lupeol, Triterpenoid.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Rifdah Nabilah
Date Deposited:	05 Aug 2021 07:09
Last Modified:	05 Aug 2021 07:10
URI:	http://repository.unsri.ac.id/id/eprint/51627

Actions (login required)

View Item