UJI EFEK TERATOGENIK EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) PADA FETUS MENCIT (Mus musculus) GALUR SUB SWISS WEBSTER

HIBSAH, HIBSAH and Herlina, Herlina and Novita, Rennie Puspa (2021) UJI EFEK TERATOGENIK EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) PADA FETUS MENCIT (Mus musculus) GALUR SUB SWISS WEBSTER. Undergraduate thesis, Sriwijaya University.

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Abstract

One of the special toxicity tests is the teratogenic test which is carried out to obtain information on the presence of fetal abnormalities that occur due to the administration of test preparations during the formation of fetal organs (organogenesis period) and to complete safety data from the melinjo plant. The dosage given is 700, 850, 1000 and 1150 mg/kgBW. The extract was administered during the organogenesis days of the 9th to 17th days of pregnancy and then the mother mice were dissected on the 18th day to observe the fetus weight, live fetus, dead fetus, implantation, resorption, fetus external abnormalities and fetus skeletal disorders. The result of statistic analysis with ANOVA and Kruskall-Wallis followed by DMRT AND Mann-Whitney showed that extract have a significant effect on pregnant mice weight gain, fetus weight, delay of supraoccipital bone, sacrocaudal vertebra body, sternum bone (shaped), sternum bone (dumbbell-shaped), anterior intermediate phalanx and posterior proximal phalanx (p<0,05). The results of the DMRT (Duncan Multiple Range Test) test showed that the dose of P2 (850 mg/kgBW) was the minimum dose that caused the teratogenic effect (p<0.05), so it could be concluded that the ethanolic extract of melinjo leaves has a teratogenic effect on the fetus of mice (Mus musculus).

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Gnetum gnemon L., teratogenik, fetus mencit, osifikasi, kehamilan
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS189-190 Assay methods. Standardization. Analysis
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Hibsah Hibsah
Date Deposited:	10 Aug 2021 01:50
Last Modified:	10 Aug 2021 01:50
URI:	http://repository.unsri.ac.id/id/eprint/51833

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