UJI AKTIVITAS ANTIDIABETES FRAKSI ETIL ASETAT DAUN BENALU RAMBUTAN (Dendrophthoe pentandra (L.) Miq) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN

SHAFARINA, GHINA RAUDYA and Fitrya, Fitrya and Agustiarini, Vitri (2021) UJI AKTIVITAS ANTIDIABETES FRAKSI ETIL ASETAT DAUN BENALU RAMBUTAN (Dendrophthoe pentandra (L.) Miq) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN. Undergraduate thesis, Sriwijaya University.

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Abstract

The rambutan mistletoes Dendrophthoe pentandra leaves are known to contain the main secondary metabolite in the form of flavonoid quercetin which has in vitro antioxidant and antidiabetic activity. The aims of this study was to determine the effectiveness of reducing blood glucose levels of the ethyl acetate fraction of D. pentandra. The ethyl acetate fraction was obtained from liquid-liquid fractionation of ethanol extract with n-hexane, ethyl acetate, and ethanol as solvents. The flavonoid content contained in ethyl acetate fraction of D. pentandra was 172.96 mgQE/g fraction and the ethanol fraction was 43.70 mgQE/g fraction. The experimental animals male Wistar white rats divided into 6 groups consisting of normal and negative control groups given 0.5% Na-CMC, positive control administered with insulin (1 IU/kgBW), and the treatment group with the ethyl acetate fraction of D. pentandra leaves with doses of 25, 50, and 100 mg/kgBW. The rats were induced by alloxan 125 mg/kgBW until their blood glucose ≥200 mg/dL, then it was administered by the ethyl acetate of rambutan mistletoes leaves for the next 14 days. The results of the percentage reduction in blood glucose levels of the ethyl acetate fraction of D. pentandra were significantly different from the negative control (p<0.05) i.e. dose of 25 mg/kgBW 40.01%; dose 50 mg/kgBW 43.67%; and dose 100 mg/kgBW 51.64% and there was no significant difference in the ethyl acetate fraction of D. pentandra 100 mg/kgBW compared to the positive control (p>0.05). The ED50 value of ethyl acetate fraction of D. pentandra leaves as antidiabetic obtained was 89.72 mg/kgBW.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	antidiabetes, benalu, Dendrophthoe pentandra, flavonoid, aloksan
Subjects:	Q Science > QP Physiology > QP(901)-(981) Experimental pharmacology R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Ghina Raudya Shafarina
Date Deposited:	06 Dec 2021 07:41
Last Modified:	06 Dec 2021 07:41
URI:	http://repository.unsri.ac.id/id/eprint/58754

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