FORMULASI SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) DAN PENENTUAN NILAI SPF SECARA IN-VITRO

YULISA, MERIZKA and Fitrya, Fitrya and Wijaya, Dina Permata (2021) FORMULASI SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) DAN PENENTUAN NILAI SPF SECARA IN-VITRO. Undergraduate thesis, Sriwijaya University.

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Abstract

Excessive sun exposure can also cause skin problems ranging from redness, inflammation and can trigger the appearance of skin cancer. One way to protect the skin from the sun is by using a sunscreen. Breadfruit leaves (Artocarpus altilis (Park.) Fosberg) contain flavonoids which can be used for sunscreen preparations. The purpose of this study was to determine the potential of sunscreen from cream preparations of ethanol extract of breadfruit leaves (Artocarpus altilis (Park.) Fosberg) with extract concentrations of 0%, 2%, 6% and 8% using the UV-Vis spectrophotometric method. The ethanol extract of breadfruit leaves was obtained by maceration using 96% ethanol. Measurement of total flavonoid content of breadfruit leaf ethanol extract obtained results of 24.0582 mg QE/g and measurement of total phenolic content obtained results of 21.5835 mg GAE/g. The effectiveness of sunscreens is based on determining the in-vitro SPF value using the Mansur equation. The SPF value of each formula is 0.0730 (ineffective); 6,1743 (moderate protection); 8,2154 (maximum protection); and 8,6284 (maximum protection). Evaluation of the physical properties of the cream preparations includes organoleptic, homogeneity, pH, viscosity, spreadability, adhesion and protection power. The correlation analysis between the SPF value and the evaluation of the preparation showed a positive linear relationship between the SPF of the cream and the spreadability of the cream and a negative linear relationship between the SPF of the cream and the pH, viscosity, and adhesion of the cream. The stability of the best formula is determined by the method of cycling test, centrifugal test, and exposure to UV rays. The results of the stability test showed stable results on the best formula from the sunscreen cream of the breadfruit leaf ethanol extract. Paparan sinar matahari berlebih menyebabkan masalah kulit kemerahan, peradangan, bahkan kanker kulit. Cara melindungi kulit dari sinar matahari yaitu menggunakan tabir surya. Daun sukun (Artocarpus altilis (Park.) Fosberg) mengandung flavonoid yang dapat dimanfaatkan untuk sediaan tabir surya. Tujuan penelitian adalah mengetahui potensi tabir surya sediaan krim ekstrak etanol daun sukun (Artocarpus altilis (Park.) Fosberg) dengan konsentrasi ekstrak sebesar 0%, 2%, 6% dan 8% menggunakan metode spektrofotometri UV-Vis. Ekstrak etanol daun sukun diberoleh dengan cara maserasi menggunakan etanol 96%. Pengukuran kadar flavonoid total ekstrak etanol daun sukun didapatkan hasil sebesar 24,0582 mg QE/g dan pengukuran kadar fenolik total didapatkan hasil sebesar 21,5835 mg GAE/g. Efektivitas tabir surya didasarkan dengan menentukan nilai SPF secara in-vitro menggunakan persamaan Mansur. Nilai SPF dari setiap formula berturut-turut adalah 0,0730 (tidak efektif); 6,1743 (proteksi sedang); 8,2154 (proteksi maksimal); dan 8,6284 (proteksi maksimal). Evaluasi sifat fisik sediaan krim meliputi organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat dan daya proteksi. Analisis korelasi antara nilai SPF dan evaluasi sediaan menunjukkan hubungan linier positif antara SPF krim dan daya sebar krim dan adanya hubungan linier negatif antara SPF krim dengan pH, viskositas, dan daya lekat krim. Stabilitas dari formula terbaik ditentukan dengan metode cycling test, centrifugal test, dan paparan terhadap sinar UV. Hasil dari uji stabilitas menunjukkan hasil yang stabil pada formula terbaik dari sediaan krim tabir surya ekstrak etanol daun sukun.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Bahan Alam, Teknologi Farmasi
Subjects:	Q Science > Q Science (General) > Q350-390 Information theory R Medicine > R Medicine (General) > R855-855.5 Medical technology R Medicine > RS Pharmacy and materia medica > RS125-131.9 Formularies. Collected prescriptions R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Merizka Yulisa
Date Deposited:	14 Dec 2021 07:36
Last Modified:	14 Dec 2021 07:36
URI:	http://repository.unsri.ac.id/id/eprint/59237

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