UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN BINJAI (Mangifera caesia Jack.) PADA TIKUS PUTIH JANTAN

KINANTI, CATRINA and Salni, Salni and Solihah, Indah (2022) UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN BINJAI (Mangifera caesia Jack.) PADA TIKUS PUTIH JANTAN. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061181823121.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061181823121_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (7MB) | Request a copy
Preview	Text RAMA_48201_08061181823121_0023086604_0008038802_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (993kB) | Preview
	Text RAMA_48201_08061181823121_0023086604_0008038802_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (642kB) | Request a copy
	Text RAMA_48201_08061181823121_0023086604_0008038802_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (380kB) | Request a copy
	Text RAMA_48201_08061181823121_0023086604_0008038802_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (521kB) | Request a copy
	Text RAMA_48201_08061181823121_0023086604_0008038802_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (87kB) | Request a copy
	Text RAMA_48201_08061181823121_0023086604_0008038802_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (341kB) | Request a copy
	Text RAMA_48201_08061181823121_0023086604_0008038802_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy

Abstract

Binjai (Mangifera caesia Jack.) is a plant that is empirically used by the people of Bangka Belitung as an alternative treatment for pain and inflammation. Binjai leaves contain secondary metabolites such as flavonoids, tannins, and steroids that have the potential as analgesic and antiinflammatory. This study aims to determine the characteristics of the extract, the effect of extract and fraction of Binjai leaves as analgesic and antiinflammatory, and the compounds in the active fraction of Binjai leaves. The Wistar rats were divided into 6 groups, namely the negative control group, the positive control group which was given 4.5 mg/KgBW of Diclofenac Sodium, the ethanol extract, the n-hexane fraction, the ethyl acetate fraction and the ethanol-water fraction at a dose of 300 mg/KgBW. Pain was created by inducing acetic acid 0.6% w/v intraperitoneally one hour after administration of the solution samples. Inflammation was created by inducing carrageenan 1% w/v subplantar one hour after administration of the solution samples. Parameters observed included the amount of writhing, %analgesic, %inflammation, and %inflammation inhibition. The data were analyzed using One Way ANOVA test to see the difference in the percentage of analgesic and antiinflammatory effects between groups. The characterization results showed that the ethanol extract of Binjai leaves met the parameter limits according to the Indonesian Ministry of Health (2008). The test results showed that the ethyl acetate fraction gave the largest percentage with analgesic percentage was 74.02% and inflammation inhibition percentage was 60.11% followed by ethanol extract, n-hexane fraction, and ethanol-water fraction. Statistical analysis stated that each parameter showed a significant difference in each group (p<0.05). It can be concluded that the ethyl acetate fraction is the most optimal fraction in providing analgesic and anti-inflammatory effects.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Mangifera caesia Jack., Analgetika, Antiinflamasi, Writhing Test, Rat Paw Edema
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Catrina Kinanti
Date Deposited:	20 Jan 2022 07:27
Last Modified:	20 Jan 2022 07:27
URI:	http://repository.unsri.ac.id/id/eprint/62040

Actions (login required)

View Item