UJI EFEK PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DAN PENENTUAN KADAR FENOLIK TOTAL EKSTRAK ETANOL TUMBUHAN PETAI (Parkia speciosa Hassk.)

CHURIA, RANNA and Fitrya, Fitrya and Sihotang, Yosua Maranatha (2018) UJI EFEK PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DAN PENENTUAN KADAR FENOLIK TOTAL EKSTRAK ETANOL TUMBUHAN PETAI (Parkia speciosa Hassk.). Undergraduate thesis, Sriwijaya University.

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Abstract

Diabetes mellitus (DM) type 2 is a metabolic disorder characterized by elevated blood sugar levels caused by cell resistance to insulin. One of type 2 diabetes mellitus therapy is drug of inhibiting activity of α-glucosidase enzyme. Petai plant (Parkia speciosa Hassk.) is one of the plants traditionally used as an antidiabetic agent. The phenolic content in petai plant has potential as an inhibiting compound of α-glucosidase enzyme activity. This study aims to determine the effectiveness of antidiabetic of ethanolic extract of pods, leaves, and petai seeds through inhibition test of α-glucosidase enzyme activity and determination of total phenolic content of extract. The result of ethanol extract test of pod, leaves, and petai seed showed inhibitory effect of α-glucosidase enzyme activity with IC50 value of each extract is 4.596 ppm (extrapolation), 54.341 ppm (extrapolation), and 67.425 ppm and the results of determining total phenolic content of ethanol extract pods, leaves, and petai seeds using Folin-Ciocalteu is 1381.5 mg GAE/g, 118.5 mg GAE/g, and 36.25 mg GAE/g. Based on the results, petai pods has the highest total phenolic content and inhibitory effect of α-glucosidase enzyme activity than leaf and petai seeds.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Parkia speciosa, α-glucosidase, total phenolic
Subjects: Q Science > QK Botany > QK1-989 Botany
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 24 Jul 2019 07:16
Last Modified: 24 Jul 2019 07:16
URI: http://repository.unsri.ac.id/id/eprint/683

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