OPTIMASI SEDIAAN GEL ETOSOM KLINDAMISIN HCl SEBAGAI ANTI JERAWAT DAN UJI AKTIVITAS ANTIBAKTERI SECARA in vitro TERHADAP BAKTERI Propionibacterium acnes

SARI, ANGGITIA LARAS and Apriani, Elsa Fitria and Shiyan, Shaum (2022) OPTIMASI SEDIAAN GEL ETOSOM KLINDAMISIN HCl SEBAGAI ANTI JERAWAT DAN UJI AKTIVITAS ANTIBAKTERI SECARA in vitro TERHADAP BAKTERI Propionibacterium acnes. Undergraduate thesis, Sriwijaya University.

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Abstract

Penggunaan klindamisin secara topikal dapat menghambat pertumbuhan bakteri Propionibacterium acnes pada jerawat. Pembuatan sediaan gel etosom Klindamisin HCl dilakukan untuk meningkatkan efek antibakterinya. Penelitian ini bertujuan untuk mengetahui karakteristik fisik formula optimum gel etosom klindamisin HCl. Penelitian ini terdapat 4 formula yang dihasilkan oleh Program Design Expert 12® dengan metode design faktorial dan ditentukan respon pH, daya sebar, daya lekat dan viskositas. formula optimum gel etosom klindamisin HCl yang diperoleh dilakukan uji sentrifugasi, cycling test dan penentuan Konsentrasi Hambat Minimum (KHM). Formula optimum sediaan gel etosom klindamisin HCl pada konsentrasi karbopol 0,5% dan HPMC 1%. Hasil sentrifugasi menunjukkan tidak adanya pemisahan fase. Hasil cycling test menunjukkan adanya kenaikan pH dari 5,25 ± 0,008 menjadi 5,33 ± 0,012. Konsentrasi Hambat Minimum dari sediaan gel etosom klindamisin HCl terjadi kekeruhan pada konsentrasi 60 µg/mL dengan diamter zona hambat sebesar 40,1667 ± 1,8409. Berdasarkan hasil penelitian, maka dapat disimpulkan bahwa formula optimum sediaan gel etosom klindamisin HCl memiliki aktivitas antibakteri yang sangat kuat dengan kategori ≥ 21 mm dan stabilitas yang baik. Kata Kunci: Klindamisin HCl, Karbopol 940, HPMC, Etosom, Antibakteri Topical usage of clindamycin can inhibit the growth of Propionibacterium acnes bacteria in acne. The preparation of clindamycin HCl ethosomal gel was carried out to increase its antibacterial effect. This study aims to determine the physical characteristics of the optimum formula of clindamycin HCl ethosomal gel. In this study, there were 4 formulas produced by Program Design Expert 12® with the factorial design method and determined by pH response, dispersion, adhesion and viscosity. The optimum formula of clindamycin HCl ethosomal gel which has been obtained was carried out by centrifugation test, cycling test and determination of Minimum Inhibitory Concentration (MIC). The optimum formula for clindamycin HCl ethosomal gel preparation at a concentration of 0.5% carbopol and 1% HPMC. The results of centrifugation showed no phase separation. The results of the cycling test showed an increase in pH from 5,25 ± 0,008 to 5,33 ± 0,012. Minimum Inhibitory Concentration of clindamycin HCl ethosomal gel preparation was turbidity at a concentration of 60 g/mL with an inhibition zone diameter of 40.1667 ± 1.8409. Based on the results of the study, it can be concluded that the optimum formula for clindamycin HCl ethosomal gel preparation has a very strong antibacterial activity with a category ≥21 mm and good stability. Keywords: Clindamycin HCl, Carbopol 940, HPMC, Ethosomes, Antibacterial

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Klindamisin HCl, Karbopol 940, HPMC, Etosom, Antibakteri
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Anggitia Laras Sari
Date Deposited:	05 Apr 2022 06:07
Last Modified:	05 Apr 2022 06:07
URI:	http://repository.unsri.ac.id/id/eprint/68479

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