PREPARASI DAN KARAKTERISASI NANOCARRIER POLY (LACTIC CO-GLICOLYC ACID) PEMBAWA ASAM USNAT DENGAN VARIASI POLYVINYL ALCOHOL MENGGUNAKAN METODE EMULSION SOLVENT EVAPORATION

ELGA, ORIN CHIA and Elfita, Elfita and Ahmadi, Adik (2022) PREPARASI DAN KARAKTERISASI NANOCARRIER POLY (LACTIC CO-GLICOLYC ACID) PEMBAWA ASAM USNAT DENGAN VARIASI POLYVINYL ALCOHOL MENGGUNAKAN METODE EMULSION SOLVENT EVAPORATION. Undergraduate thesis, Universitas Sriwijaya.

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Abstract

Usnic acid has low solubility and has potential as a drug because of its antibiotic, antifungal, antiviral, anti-inflammatory, analgesic, antipyretic, antiproliferative, and cytotoxic effects. Development of nanocarrier delivery system with PLGA polymer and PVA stabilizer to overcome the low solubility of usnic acid. This study aims to obtain the best formula for usnic acid nanocarrier which has good characteristics and stability. Usnic acid was characterized. In this study there were 3 formulas with PVA variations of 0.05%, 0.1% and 0.15%. The manufacture of usnic acid nanocarriers was carried out using the emulsion solvent evaporation method and characterization and determination of the percentage of adsorption efficiency were carried out to obtain the best formula. The best formula was carried out by particle characterization and stability test. Usnic acid is in the form of yellow crystals with a melting point of 204.3-204.8°C, Rf 0.45 and a maximum absorption wavelength of 230 nm in methanol and 287 nm in water. The results of the percent adsorption efficiency of formulas 1, 2 and 3 showed values of 96%, 92% and 89% respectively. The best formula for usnic acid nanocarrier was found in formula 1 with a PVA concentration of 0.05%. The result of particle characterization of usnic acid nanocarrier showed particle size of 435.8 nm, polydispersity index of 0.328 and zeta potential of -11.4 mV and increased solubility after the development of preparations in the form of asm usnat nanocarrier. The results of the stability test showed that the usnic acid nanocarrier was stable in three storage conditions with a release model following the 0th order, energy 23.42 cal/mol, kinetic constant 0.0338 mg/day at 25°C with a shelf life of 57 days and prediction at a temperature of 5°C with a shelf life of 70 days. Based on the results of parametric statistical analysis using one-way ANOVA showed a p value <0.05, so it can be concluded that the variation of PVA concentration has a significant effect on determining the best formula produced. Keywords: Nanocarrier, Usnic Acid, PLGA, PVA, Emulsion Sovent Evaporation Asam usnat memiliki kelarutan yang rendah dan berpotensi sebagai obat karena memiliki aktivitas sebagai antibiotik, antijamur, antivirus, antiinflamasi, analgesik, antipiretik, antipoliferatif, dan efek sitotoksik. Pengembangan sistem penghantaran nanocarrier dengan polimer PLGA dan stabilizer PVA untuk mengatasi rendahnya kelarutan asam usnat. Penelitian ini bertujuan untuk memproleh formula terbaik nanocarrier asam usnat yang memiliki karakteristik dan stabilitas yang baik. Asam usnat dilakukan karakterisasi. Penelitian ini terdapat 3 formula dengan variasi PVA sebesar 0,05%, 0,1% dan 0,15%. Pembuatan nanocarrier asam usnat dilakukan dengan metode emulsion solvent evaporation dan dilakukan karakterisasi serta penentuan persen efisiensi penjerapan untuk memproleh formula terbaik. Formula terbaik dilakukan karakterisasi partikel dan uji stabilitas. Asam usnat berbentuk kristal kuning dengan titik lebur 204,3-204,8°C, Rf 0,45 dan panjang gelombang serapan maksimum sebesar 230 nm dalam metanol dan 287 nm dalam air. Hasil persen efisiensi penjerapan formula 1, 2 dan 3 menunjukkan nilai berturut-turut sebesar 96%, 92% dan 89%. Formula terbaik nanocarrier asam usnat terdapat pada formula 1 dengan konsentrasi PVA 0,05%. Hasil karakterisasi partikel nanocarrier asam usnat menunjukkan ukuran partikel sebesar 435,8 nm, indeks polidispersitas sebesar 0,328 dan zeta potensial -11,4 mV dan kelarutan yang meningkat setelah dilakukan pengembangan sediaan dalam bentuk nanocarrier asm usnat. Hasil uji stabilitas menunjukkan nanocarrier asam usnat stabil pada tiga kondisi penyimpanan dengan model pelepasan mengikuti orde-0, energi 23,42 cal/mol, konstanta kinetika 0,0338 mg/hari pada suhu 25°C dengan masa simpan 57 hari dan prediksi pada suhu 5°C dengan masa simpan 70 hari. Berdasarkan hasil analisis statistik parametrik menggunakan ANOVA satu arah menunjukkan nilai p<0,05 sehingga dapat disimpulkan bahwa variasi konsentrasi PVA berpengaruh signifikan terhadap penentuan formula terbaik yang dihasilkan. Kata Kunci: Nanocarrier, Asam Usnat, PLGA, PVA, Emulsion Sovent Evaporation

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Nanocarrier, Asam Usnat, PLGA, PVA, Emulsion Sovent Evaporation
Subjects: R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: ORIN CHIA ELGA
Date Deposited: 05 Apr 2022 06:02
Last Modified: 05 Apr 2022 06:02
URI: http://repository.unsri.ac.id/id/eprint/68485

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