ISOLASI SENYAWA STEROID DARI TANAMAN Gynura pseudochina (Lour) DC DAN UJI AKTIVITAS ANALGETIKA TERHADAP MENCIT JANTAN (Mus musculus)

GULTOM, ROBY PAHALA JANUARIO and Herlina, Herlina and Ferlinahayati, Ferlinahayati (2012) ISOLASI SENYAWA STEROID DARI TANAMAN Gynura pseudochina (Lour) DC DAN UJI AKTIVITAS ANALGETIKA TERHADAP MENCIT JANTAN (Mus musculus). Undergraduate thesis, Sriwijaya University.

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Abstract

The secondary metabolites have been isolated from nonpolar fraction of methanol extract of Gynura pseudochina (Lour) DC plants. The extraction was done by maseration. Separation and purification were done by column chromatography. The isolated compound was a white solids with melting point 123 °C-125°C. The structure of this compound was determined based on spectral evidence including IR, 13C-NMR, 'H-NMR, HSQC, HMBC and COSY. The spectral data analysis were suggested that the isolated compound is a mixture of two steroids which is stigmast-5-en-3-ol or (3-sitosterol as a major compound. The analgesic activity of the isolated compound was tested in male mice by writhing test method with 1% acetic acid as the pain-inducer. The isolated compound showed that pain-inhibition activity were 56,2 % for 2 mg/20 g BB dose and 67 % for 4 mg/20 g BB dose. The analgesic activity of the isolated compound is lower thanthe aspirin. Key words: Gynura pseudochina (Lour) DC, Steroid, Stigmast-5-en-3-ol, analgesic activity.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Gynura pseudochina (Lour) DC, Steroid, Stigmast-5-en-3-ol, analgesic activity.
Subjects:	Q Science > QK Botany > QK1-989 Botany
Divisions:	08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User:	Mrs Beta Ria Febrianti
Date Deposited:	17 May 2022 01:26
Last Modified:	17 May 2022 01:26
URI:	http://repository.unsri.ac.id/id/eprint/70089

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