UJI AKTIVITAS SEDIAAN SPRAY-GEL EKSTRAK ETANOL DAUN SALAM (SYZYGIUM POLYANTHUM) TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS PUTIH JANTAN GALUR SPRAGUE DAWLEY

ELVARIANI, VENNY and Herlina, Herlina and Wijaya, Dina Permata (2022) UJI AKTIVITAS SEDIAAN SPRAY-GEL EKSTRAK ETANOL DAUN SALAM (SYZYGIUM POLYANTHUM) TERHADAP PENYEMBUHAN LUKA TERBUKA PADA TIKUS PUTIH JANTAN GALUR SPRAGUE DAWLEY. Undergraduate thesis, Sriwijaya University.

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Abstract

Wounds can cause damage or loss of continuity of body tissues. Plants used in wound healing are derived from bay leaves (Syzygium polyanthum) which acts as an anti-inflammatory, antioxidant, and antibacterial. This study aims to obtain the best formula for spray gel on the healing of open wounds. The ethanol extract of bay leaf was characterized by extract.preparation spray gel , the concentration of the ethanol extract was varied by 10%, 15%, 20%, and 25%. Preparation of spray Gel preparations were evaluated and data were analyzed to obtain the best formula. The results of the characterization of the extract showed the presence of flavonoid compounds, water content of 6%, water soluble extract content of 53.34%, ethanol soluble extract content of 76.67%, total ash content and acid insoluble 2.16% and 0.18%, contamination microbial contamination by 0 %, and metal contamination by 0%. The best formula for spray gel with the highest percent healing was found at a concentration of 25% with adhesion value > 60 seconds, pH 4.667 ± 0.00471, viscosity 757 cPs, pump delivery 0.093 ± 0.00471 g, spraying pattern 1.100 ± 0.0816 cm, washability 2.46 ± 0.0471 mL, and has a wound healing effect within 12 days. Based on the research result , it can be concluded that the best formula has good dosage characteristics and has activity to accelerate the healing of open wounds. Keywords: open wound, bay leaf, spray-gel, carbopol®940. Luka dapat menyebabkan terjadinya kerusakan atau hilangnya kontinuitas jaringan tubuh. Tumbuhan yang digunakan dalam penyembuhan luka berasal dari daun salam (Syzygium polyanthum) yang beraktivitas sebagai antiinflamasi, antioksidan, dan antibakteri. Penelitian ini bertujuan untuk mendapatkan formula terbaik sediaan spray gel terhadap penyembuhan luka terbuka. Ekstrak etanol daun salam dilakukan karakterisasi ekstrak. Pembuatan sediaan spray gel dilakukan variasi konsentrasi ekstrak etanol sebesar 10%, 15%, 20%, dan 25%. Sediaan spray gel dilakukan evaluasi sediaan serta dilakukan analisis data untuk memperoleh formula terbaik. Hasil karakterisasi ekstrak menunjukan adanya senyawa flavonoid, kadar air sebesar 6%, kadar sari larut air 53,34%, kadar sari larut etanol 76,67%, kadar abu total dan tidak larut asam 2,16% dan 0,18%, cemaran mikroba sebsar 0, dan cemaran logam sebesar 0. Formula terbaik sediaan spray gel dengan persen penyembuhan tertinggi terdapat pada konsentrasi 25% dengan nilai daya lekat > 60 detik, pH sebesar 4,667 ± 0,00471, viskositas 757 cPs, pump delivery 0,093 ± 0,00471 g, pola penyemprotan 1,100 ± 0,0816 cm, daya tercuci 2,46 ± 0,0471 mL, serta memiliki efek penyembuhan luka dalam waktu 12 hari. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa formula terbaik memiliki karakteristik sediaan yang baik dan memiliki aktivitas untuk mempercepat penyembuhan luka terbuka. Kata kunci: luka terbuka, daun salam, spray gel, carbopol®940.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Teknologi Farmasi, Farmakologi, Bahan Alam
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Venny Elvariani
Date Deposited:	02 Jun 2022 06:41
Last Modified:	02 Jun 2022 06:41
URI:	http://repository.unsri.ac.id/id/eprint/71276

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