AKTIVITAS ANTIDIARE FRAKSI ETANOL DAUN MELINJO (GNETUM GNEMON L. (LINN.)) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI BAKTERI SALMONELLA TYPHI

AMIRAH, LUTHFIYAH and Herlina, Herlina and Shiyan, Shaum (2022) AKTIVITAS ANTIDIARE FRAKSI ETANOL DAUN MELINJO (GNETUM GNEMON L. (LINN.)) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI BAKTERI SALMONELLA TYPHI. Undergraduate thesis, Sriwijaya University.

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Abstract

One of the plants that can be used to treat diarrhea is melinjo (Gnetum gnemon L. (Linn.)). Tannin compounds in melinjo leaves which are astringent are thought to have antidiarrheal effects. This study aimed to evaluate the antidiarrheal activity of the ethanol fraction of melinjo leaves. This study used male white rats of wistar strain induced by S.typhi bacteria. The test animals were divided into 6 groups, namely a negative control group (1% NaCMC), a positive control group (Chloramphenicol), and 4 treatment groups at doses of 30, 60, 90, and 120 mg/kgBW. The results of the characterization of the ethanol fraction of melinjo leaves obtained water soluble extract content of 39.33%; ethanol soluble extract content of 24,00%; water content 7.67%; drying shrinkage 8.32%; total ash content of 8.00%; acid insoluble ash content 7.51%; microbial contamination test 0 cfu/g; and test for metal contamination of Pb <0.068 mg/kg. Doses of 30 mg/kgBW and 60 mg/kgBW were able to reduce the number of bacterial colonies with the number of colonies of 18.4 x 105 and 14 x 105 (cfu g-1). The results of statistical analysis of doses of 90 mg/kgBW and 120 mg/kgBW had no significant difference with the positive control group (p>0.05) and were able to reduce the number of bacterial colonies equivalent to the positive control group to zero after 12 days of treatment. The dose of 120 mg/kgBW was the most effective as antidiarrheal based on the observed parameters of antidiarrheal activity. The total tannin content contained in the ethanol fraction of melinjo leaves was 165,736 mgTAE/g fraction. The effective dose (ED50) of the ethanol fraction of melinjo leaves as an antidiarrheal was 111,724 mg/kgBW. Keywords: Melinjo leaves, antidiarrheal, ethanol fraction, Salmonella typhi

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun melinjo, antidiare, fraksi etanol, Salmonella typhi
Subjects:	Q Science > QR Microbiology Q Science > QR Microbiology > QR75-99.5 Bacteria R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Luthfiyah Amirah
Date Deposited:	04 Aug 2022 06:23
Last Modified:	04 Aug 2022 06:23
URI:	http://repository.unsri.ac.id/id/eprint/76070

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